Molecular Formula | C11H9NO3 |
Molar Mass | 203.19 |
Density | 1.341±0.06 g/cm3(Predicted) |
Boling Point | 404.4±25.0 °C(Predicted) |
Flash Point | 198.4°C |
Vapor Presure | 9.46E-07mmHg at 25°C |
pKa | 14.59±0.30(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.677 |
use | methyl 3-aldehyde indole-5-formate is a carboxylate derivative, Can be used as an intermediate in pharmaceutical and chemical industry. |
preparation | methyl 3-aldehyde indole-5-formate as a derivative of indole-3-formaldehyde has not been reported in the literature. According to the molecular structure characteristics of compound 1, methyl 3-methyl -4-nitrobenzoate was prepared by esterification of 3-methyl -4-nitrobenzoate with 3-methyl -4-nitrobenzoate. compound 2 was condensed with N,N-dimethylformamide diethyl acetal (DMFDEA) and piperidine after being reduced by iron powder and glacial acetic acid to obtain methyl indole -5-formate. finally compound 4 was synthesized by Vilsmeier-Hacck reaction with phosphorus oxychloride and N,N-dimethylformamide, the process route is simple to operate, high yield, suitable for industrial production. The roadmap for synthesis of 3-aldehyde indole -5-methyl formate is as follows: |