Name | Ozagrel sodium |
Synonyms | Ozapen D01684 Athrombone Ozapen (tn) OZAGREL SODIUM Ozagrel sodium Ozagrel sodium (jan) sodium (E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)acrylate sodium (2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]prop-2-enoate (E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]acrylic acid sodium salt (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid sodium salt |
CAS | 189224-26-8 130952-46-4 |
EINECS | 1806241-263-5 |
InChI | InChI=1/C13H12N2O2.Na/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15;/h1-8,10H,9H2,(H,16,17);/q;+1/b6-5+ |
Molecular Formula | C13H11N2NaO2 |
Molar Mass | 250.23 |
Storage Condition | -20℃ |
White Crystal or crystalline powder, odorless, sour bitter. Soluble in water, soluble in methanol, almost insoluble in ethanol, acetone or ether.
using p-methylbenzaldehyde as a raw material, the mixture was subjected to aldol condensation with acetic anhydride, followed by dehydration to obtain 3 pairs of tolylacrylic acid, which was esterified to ethyl 3-p-tolylacrylate. Sodium ozagrel was obtained by hydrolysis of N-bromosuccinimide bromination with benzoyl peroxide as initiator and reaction with imidazole.
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.996 ml | 19.982 ml | 39.964 ml |
5 mM | 0.799 ml | 3.996 ml | 7.993 ml |
10 mM | 0.4 ml | 1.998 ml | 3.996 ml |
5 mM | 0.08 ml | 0.4 ml | 0.799 ml |
developed by nipponao Pharmaceutical Industry Co., Ltd., was first launched in Japan in April 1988. Potent thromboxane synthase inhibitors. By inhibiting thromboxane synthase, lowering thromboxane A2(TXA2) in vivo, and promoting the production of prostacyclin (PGI2), to fight against the aggregation of platelets and spasm of cerebral vessels, however, it had little effect on other arachidonic acid metabolizing enzymes such as cyclooxygenase. For the improvement of vasospasm after subarachnoid hemorrhage surgery and its complicated cerebral ischemia symptoms.
male and female mice, male and female rats LD50 (mg/kg): 1940, 1580, 1150, 1300 intravenous injection; 3800, 3600, 5900, 5700 oral; 2450, 2250, 0.