Name | beta.-Cyclodextrin, sulfobutyl ethers, sodium salts |
Synonyms | SBE7-beta-CD sulfobutyl ether sodium salt BETADEX SULFOBUTYL ETHER SOIDUM betadex sulfobuytl ether sodium β-Cyclodextrin, sulfobutyl ethers Sodium sulfobutylether β-cyclodextrin Sulfobutylated beta-cyclodextrin sodium salt (DS~4) Sulfobutylated beta-cyclodextrin sodium salt (DS~6) beta.-Cyclodextrin, sulfobutyl ethers, sodium salts .beta.-Cyclodextrin, sulfobutyl ethers, sodium salts SBE-β-CD(Sulfobutyl Ether-β-cyclodextrin Sodium salt) |
CAS | 182410-00-0 194615-04-8 |
EINECS | 1308068-626-2 |
Molecular Formula | C42H70O35 |
Molar Mass | 1134.9842 |
Melting Point | 202-204°C (dec.) |
Solubility | Soluble in water. Insoluble in acetone, methanol, chloroform. |
Appearance | Solid powder |
Color | White to off white |
Storage Condition | Inert atmosphere,Room Temperature |
Use | SBE- β-CD is a chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs. |
In vitro study | SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range. |
In vivo study | 20% SBE-β-CD in saline: Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution. 2. Measure 2 g of dry SBE-β-CD. 3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use. |
HS Code | 2940006000 |
Reference Show more | 1. Zheng Xiaoxia, He Xiaohua, Huang Yanni et al. Pharmacokinetics of lansoprazole sodium enantiomers in dogs [J]. Chinese Pharmacist 2020(8). 2. Yang Peng, Lu Song, Wang Zhan, et al. Study on thermal stability and thermal decomposition kinetics of sulfobutyl-β-cyclodextrin [J]. Grain and Oil, 2018, 31(11):45-48. 3. Lu Lanfang, Yang Peng, Wang Zhan, et al. Phase solubility method to study the solubilization of cyclodextrin on kaempferol [J]. China Seasoning, 2019, 044(006):65-69. 4. Wu Chuanhong, Zhong Ruixue, Wei Tingsen, Wang Xiaoling. Preparation and Characterization of Inclusion Compound of Peppermint Oil-Sulfobutyl Ether-β-Cyclodextrin [J]. China Food Additives, 2020,31(09):14-18. 5. Yang Dan, Feng Liang, Liu Jun, Zhao Jing, Li Chao, Zhu Fagen, Shao Jianguo, Jia Xiaobin, Sun E. Study on Improvement of Drug Compliance of Pudilan Anti-inflammatory Oral Liquid for Children Based on Material Property Characterization Technology [J]. World Chinese Medicine, 2020,15(15):2221-2227. 6. Zheng Xiaoxia, He Xiaohua, Huang Yanni, Cheng Yanling. Pharmacokinetics of lansoprazole sodium enantiomers in dogs [J]. Chinese Pharmacist, 2020,23(08):1665-1668. 7. Liu Zhongbo. Construction of Food Grade Pickering Emulsion Based on Cyclodextrin [D]. Henan Institute of Science and Technology, 2021. 8. Han Dongxu, Li Tianle, Miao Ruidan, Wang Yao, Liu Liyan, Yu Zhan. Solubilization of seven-(2, 6-dimethyl)-β-cyclodextrin to luteolin [J]. Chinese modern applied pharmacy, 2020,37(22):2747-2751. 9. Xiao, Sirui, et al. "Increased microneedle-mediated transdermal delivery of tetramethylpyrazine to the brain, combined with borneol and iontophoresis, for MCAO prevention." International journal of pharmaceutics 575 (2020): 118962.https://doi.org/10.1016/j 10. [IF = 4.952] Fansheng Kong et al. "Inclusion complex of grape seeds extracts with sulfobutyl ether β-cyclodextrin: Preparation, characterization, stability and evaluation of α-glucosidase and α-amylase inhibitory effects in vitro." Lwt Food Sci Technol. 2019 Mar;101:819 11. [IF = 6.751] Ting Lei et al. "Rislenemdaz treatment in the lateral habenula improves despair-like behavior in mice." Neuropsychopharmacol. 2020 Mar;45(10):1717-1724 12. [IF = 5.875] Sirui Xiao et al. "Increased microneedle-mediated transdermal delivery of tetramethylpyrazine to the brain, combined with borneol and iontophoresis, for MCAO prevention." Int J Pharmaceut. 2020 Feb;575:118962 13. [IF = 2.72] Wenjin Zhu et al. "Development and physicochemical characterization of chitosan hydrochloride/sulfobutyl ether-β-cyclodextrin nanoparticles for cinnamaldehyde entrapment." J Food Biochem. 2020 Jun;44(6):e13197 |