1-(TERT-BUTOXYCARBONYL)INDOLE-3-BORONIC ACID (MIDA-Boronic Acid for short) is an organic boron compound with the following properties:
1. Structure: It is a white solid with a chemical formula of C12H17BNO4 and a molecular weight of 249.08g/mol.
2. Stability: MIDA-Boronic Acid is very stable under regular experimental conditions and can be stored for a long time.
3. Solubility: It is soluble in most organic solvents (such as dichloromethane, ether, N,N-dimethylformamide, etc.), but insoluble in water.
4. Use: MIDA-Boronic Acid is an important intermediate in the field of organic synthesis. It can participate in metal-catalyzed cross-coupling reactions (such as Suzuki reaction and stile reaction) for the synthesis of complex organic molecules, ligands and polypeptides.
5. Preparation method: Generally, MIDA-Boronic Acid is synthesized by reacting MIDA(N-methyl pyrazine -2-carboxamide) with the corresponding aryl or Alkyl Borate under alkaline conditions.
6. Safety Information: MIDA-Boronic Acid is a relatively safe compound, it is still necessary to follow general laboratory safety procedures to avoid contact with eyes, skin and inhalation. During handling and storage, care should be taken to prevent contact with strong oxidants and oxygen to avoid unnecessary hazards.