17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol diacetate
ethynodiol diacetate
CAS: 297-76-7
Molecular Formula: C24H32O4
17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol diacetate - Names and Identifiers
17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol diacetate - Physico-chemical Properties
| Molecular Formula | C24H32O4 |
| Molar Mass | 384.51 |
| Density | 1.0474 (rough estimate) |
| Melting Point | ~126-127° |
| Boling Point | 431.17°C (rough estimate) |
| Specific Rotation(α) | D -72.5° (chloroform) |
| Flash Point | 224.2°C |
| Water Solubility | 1.4mg/L(25 ºC) |
| Solubility | DMSO 77 mg/mL Water 77 mg/mL Ethanol <1 mg/mL |
| Vapor Presure | 8.11E-09mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White |
| Storage Condition | 2-8°C |
| Refractive Index | 1.4860 (estimate) |
| In vitro study | Nordihydroguaiaretic acid (NDGA) (< 1.5 μm) decreased the sister chromatid exchange rate (SCEs) in human lymphocytes treated with 150 μg/mL ethynodiol diacetate. NDGA treatment in the presence of S9 mixture will reduce the genotoxic damage caused by ethynodiol diacetate, this may be achieved by inhibition of cytochrome P450s, which prevents the metabolic activation of ethynodiol diacetate, or by NDGA's free radical scavenging function. Ethynodiol diacetate (150 μg/mL) increases sister chromatid exchange rate (SCEs) and chromosomal aberrations (CAs) in human lymphocytes in the presence of S9 mixture frequency and can inhibit lymphocyte proliferation. |
| In vivo study | Hynodiol diacetate at a dose of 6 mg/kg per day can significantly increase the content of A- homo-3-oxa-5alpha-pregnane-4 and 20-dione in the urine of female rats, and can also significantly increase the weight of the pituitary gland, liver and kidney of rats. Combination of Norgestrel (75 μg/day) with ethynodiol diacetate (150 μg/day) and ethinyl estradiol (7.5 μg/day) reduces plasma concentrations of high-density lipoprotein cholesterol in cynomolgus monkeys |
17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol diacetate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S22 - Do not breathe dust. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | RC8963000 |
| HS Code | 2937230000 |
17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol diacetate - Introduction
Ethynodiol diacetate is one of the first synthetic contraceptive progestin.
Last Update：2022-10-16 17:24:21
17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol diacetate - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Ethynodiol diacetate (8080 CB) is one of the first synthetic progesterone for contraceptives. |
| Target | Value |
Last Update：2024-04-09 15:16:49
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View History
17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol diacetate
Metanilamide, 6-sulfanilyl-
N-[5-[bis(2-butoxyethyl)amino]-2-[(5-nitrothiazol-2-yl)azo]phenyl]acetamide
1H-Isoindole-1,3(2H)-dione, 2-[2-(4-fluorophenoxy)ethyl]-
Ripretinib Impurity 51
3-(5-METHYL-4-NITRO-1H-PYRAZOL-1-YL)PROPANOHYDRAZIDE
674792-08-6
(3S,6S)-3-Vinyl-3-methyl-6-isopropyl-2-(1-methylethylidene)cyclohexanone
tert-butyl 4-[tert-butyl(diphenyl)silyl]oxycyclohexane-1-carboxylate
ANTI-CHICKEN IGG (GAMMA-CHAIN SPECIFIC)
Metanilamide, 6-sulfanilyl-
N-[5-[bis(2-butoxyethyl)amino]-2-[(5-nitrothiazol-2-yl)azo]phenyl]acetamide
1H-Isoindole-1,3(2H)-dione, 2-[2-(4-fluorophenoxy)ethyl]-
Ripretinib Impurity 51
3-(5-METHYL-4-NITRO-1H-PYRAZOL-1-YL)PROPANOHYDRAZIDE
674792-08-6
(3S,6S)-3-Vinyl-3-methyl-6-isopropyl-2-(1-methylethylidene)cyclohexanone
tert-butyl 4-[tert-butyl(diphenyl)silyl]oxycyclohexane-1-carboxylate
ANTI-CHICKEN IGG (GAMMA-CHAIN SPECIFIC)