Molecular Formula | C14H7ClF2N4O2 |
Molar Mass | 336.68 |
Density | 1.616 |
Melting Point | 242-244℃ |
Boling Point | 489℃ |
Flash Point | 249℃ |
Solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
Vapor Presure | 0mmHg at 25°C |
Appearance | Solid |
Color | Yellow to Dark Yellow |
pKa | 5.07±0.70(Predicted) |
Storage Condition | 2-8°C(protect from light) |
Refractive Index | 1.707 |
Use | N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamide is an intermediate in the synthesis of afatinib, afatinib is an aminocrotonyl amino-substituted quinazoline derivative, used to treat cancers and diseases of the respiratory tract and lungs, gastrointestinal tract, bile duct and gallbladder. |