Molecular Formula | C14H19NO4 |
Molar Mass | 265.31 |
Density | 1.1356 (rough estimate) |
Melting Point | 123.4 °C |
Boling Point | 408.52°C (rough estimate) |
Flash Point | 209.8°C |
Vapor Presure | 6.42E-08mmHg at 25°C |
Appearance | Powder |
Color | White |
BRN | 5404389 |
pKa | 4.32±0.10(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.5110 (estimate) |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
HS Code | 29242990 |
Hazard Class | IRRITANT |
use | (R)-Boc-beta-phenylalanine is an amino acid derivative and can be used as an organic intermediate. |
preparation | (R)-3-amino -3-phenylpropionic acid (2.1g, 12.7 mmol, 1.0 equiv.) and NaHCO3 (1.6g, 19 mmol, 1.5 equiv.) were dissolved in water (30 mL). Dioxane (30 mL) and [(CH3)3CO2C]2O (4.1g, 19 mmol, 1.5 equiv.) were added to the reaction mixture. The solution was stirred at room temperature for 8 hours. The complete conversion of (R)-3-amino-3-phenylpropionic acid was confirmed by TLC (SiO2, 50/25/25 n-BuOH/HOAc/H2O). Remove the solvent by rotary evaporation. Distribute the crude mixture between HCl (1%) and EtOAc . The water layer was extracted with EtOAc. The combined organic extracts were dried with Na2SO4. Filter and concentrate the solvent. The crude product was purified by column chromatography and eluted with 10% CH3OH/DCM to obtain (R)-Boc-beta-phenylalanine. |