Name | 2-Amino-3-picoline |
Synonyms | AURORA KA-876 2-Amino-3-picoline 2-Amino-beta-picoline 3-methyl-2-pyridinamin 3-methyl-2-pyridylamine 3-Methyl-2-pyridinamine 2-Amino-3-methylpyridine 2-amino-3-methyl-pyridin 2-Pyridinamine,3-methyl- 3-Methyl-2-aminopyridine 2-amino-3-methylpyridinium |
CAS | 1603-40-3 |
EINECS | 216-501-4 |
InChI | InChI=1/C6H8N2/c1-5-3-2-4-8-6(5)7/h2-4H,1H3,(H2,7,8)/p+1 |
InChIKey | RGDQRXPEZUNWHX-UHFFFAOYSA-N |
Molecular Formula | C6H8N2 |
Molar Mass | 108.14 |
Density | 1.073 g/mL at 25 °C (lit.) |
Melting Point | 29-31 °C (lit.) |
Boling Point | 221-222 °C (lit.) |
Flash Point | 233°F |
Water Solubility | SOLUBLE |
Solubility | 1000g/l |
Vapor Presure | 0.11mmHg at 25°C |
Appearance | Liquid After Melting |
Color | Clear yellow |
BRN | 107892 |
pKa | pK1: 7.24(+1) (25°C) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Sensitive | Hygroscopic |
Refractive Index | n20/D 1.5823(lit.) |
Physical and Chemical Properties | Colorless to light yellow liquid or crystal |
Hazard Symbols | T - Toxic |
Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R33 - Danger of cumulative effects R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed |
Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection S28A - S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | US1850000 |
TSCA | Yes |
HS Code | 29333999 |
Hazard Class | 6.1 |
Packing Group | II |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
introduction | 2-amino-3-methylpyridine is an important organic intermediate, which can be used to synthesize antibacterial drugs, analgesics, anti-asthma drugs, anti-HIV drugs, and nitric oxide synthase inhibitors. 2-Amino-3-methylpyridine is also an inhibitor of nitric oxide synthase. Recently, it has been reported that this compound is an excellent solubilizer for dissolving carbon nanotube materials. |
application | 2-amino -5-methylpyridine has a wide range of applications in the fields of pesticides and medicine. it is a crucial intermediate for the synthesis of imidacloprid, pyridoxine, high-efficiency new pesticides of hydroxypentoxazole and new pesticides containing fluoropyridine in the future. |
Preparation method | The mixed aminopyridine composed of 2-amino -3-methylpyridine and 2-amino -5-methylpyridine (where the mass fraction of 2-amino -3-methylpyridine is 25%, and the mass fraction of 2-amino -5-methylpyridine is 75%) is introduced into the crystallizer, and the temperature is gradually increased to 85 ℃, after the mixed aminopyridine is completely dissolved, the temperature is gradually cooled to 35 ℃, and the cooling rate is 25 ℃/h. Then filter, wash and dry to obtain 2-amino-5-methylpyridine with a purity of 99.61%. The crystallization mother liquor is introduced into the rectification tower, the top pressure of the rectification tower is 20 KPa, the theoretical plate number is 42, the reflux ratio is 7 for rectification, and the top of the tower is 2-amino -3-methyl pyridine with a mass fraction of 99.12% is obtained. |
category | toxic substances |
toxicity classification | highly toxic |
acute toxicity | oral-rat LD50: 100 mg/kg; Subcutaneous-mouse LD50: 36 mg/kg |
flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxide smoke |
storage and transportation characteristics | warehouse ventilation and low temperature drying |
fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |