Name | Pizotifen |
Synonyms | BC 105 Pizotifen PIZOTIFEN Pizotylene Sanomigran Sandomigran Pizotifenum PIZOTHIFENUM 4-OXO-9,10-DIHYDRO-4H-BENZO(4,5) CYCLOHEPTO(1,2,B) THIOPHENE 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine |
CAS | 15574-96-6 |
EINECS | 239-632-9 |
InChI | InChI=1/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3 |
Molecular Formula | C19H21NS |
Molar Mass | 295.44 |
Density | 1.164±0.06 g/cm3(Predicted) |
Melting Point | 140-142°C |
Boling Point | 436.7±45.0 °C(Predicted) |
Flash Point | 217.9°C |
Solubility | DMSO: ≥8mg/mL |
Vapor Presure | 7.92E-08mmHg at 25°C |
Appearance | powder |
Color | White to Off-White |
Merck | 14,7515 |
pKa | pKa 6.95 (Uncertain) |
Storage Condition | room temp |
Refractive Index | 1.63 |
Physical and Chemical Properties | White needle-like crystals, odorless, bitter. Melting point 147.5-151.5 °c. Soluble in ethanol, chloroform and other organic solvents or acid solution, insoluble in water. 2-chloromethylthiophene was synthesized by multi-step reaction. For analgesics. Mainly for the treatment of typical and atypical migraine, can also be used for chronic urticaria, atrial and ventricular premature beat. |
Use | Used as an anti-migraine drug |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed R63 - Possible risk of harm to the unborn child |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37 - Wear suitable protective clothing and gloves. |
WGK Germany | 3 |
RTECS | TM7165000 |
This product is 1-methyl -4-[9, 10-dihydrobenzo [4,5]-cycloheptrieno [1,2-6]-thiophene + subunit]-piperidine. Calculated as dried product, the content of C19H21NS shall not be less than 98.5%.
The melting point of this product (General 0612) is 147~152°C.
take this product, precision weighing, and hydrochloric acid solution (0.9-1000) dissolved and quantitatively diluted into about 10ug solution per lml, the absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General rule 582), and the absorption coefficient was 618.
take this product, add ethanol to dissolve and make a solution containing lOmg per lml, as a test solution; Take the appropriate amount of precision, quantitative dilution with ethanol was made to contain 0.10 mg solution, as a control solution. According to the thin layer chromatography (General 0502) test, absorb the above two solutions of 10 u1, respectively, on the same silica gel G thin layer plate, with n-butanol-acetic acid-water (4:1:5) for the developer, expand, dry, set iodine vapor color. If the test solution shows impurity spots, the color should not be deeper compared with the main spots of the control solution.
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
not more than 0.1% (General rule 0841).
take this product about 0.2g, precision weighing, add glacial acetic acid 10ml dissolved, add crystal violet indicator liquid 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 29.54mg of C19H21NS.
anti-migraine drugs.
light shielding, sealed storage.
This product contains 90.0% ~ 110.0% of the labeled amount of benzene (C19H21NS).
This product is sugar-coated tablets, White after removing the coating.
take this product, remove the coating, dilute, weigh an appropriate amount (equivalent to 20mg of phenylidine), add chloroform 20ml, shake to dissolve the phenylidine, separate the chloroform layer, after filtration, the filtrate was evaporated to dryness, and the residue showed the same reaction according to the tests of identification (1) and (3) under the item of benzothiazide.
Take 20 tablets of this product, remove the coating, precision weighing, fine, precision weighing an appropriate amount (equivalent to 5mg ), put it in a 100ml measuring flask, add O.Olmol/L hydrochloric acid solution (70ml), fully shake to dissolve meperidine, dilute with 0.01mol/L hydrochloric acid solution to the scale, shake well, filter, and take 10ml of continued filtrate with precision, in a 50ml measuring flask, use O.Olmol/L hydrochloric acid solution is diluted to the scale, shake well, according to UV-visible spectrophotometry (General 0401 ), absorbance is measured at the wavelength of 230nm, according to the absorption coefficient of C19H21NS is 600, that's right.
Same as fenthiazide.
0.5mg
light shielding, sealed storage.