Name | 1-aminoisoquinoline |
Synonyms | 1-isoquinolylamine Isoquinolin-1-amine 1-Aminoisoquinoline 1-AMINOISOQUINOLINE 1-aminoisoquinoline ISOQUINOLIN-1-AMINE TIMTEC-BB SBB004129 Isoquinoline-1-amine ISOQUINOLIN-1-YLAMINE |
CAS | 1532-84-9 |
EINECS | 216-243-2 |
InChI | InChI=1/C9H8N2/c10-9-8-4-2-1-3-7(8)5-6-11-9/h1-6H,(H2,10,11) |
InChIKey | OSILBMSORKFRTB-UHFFFAOYSA-N |
Molecular Formula | C9H8N2 |
Molar Mass | 144.17 |
Density | 1.1148 (estimate) |
Melting Point | 122-124 °C (lit.) |
Boling Point | 166°C/8mmHg(lit.) |
Flash Point | 175.8°C |
Vapor Presure | 0.000253mmHg at 25°C |
Appearance | Yellow to brown powder or crystal |
Color | Light yellow to Brown to Dark green |
Maximum wavelength(λmax) | ['335nm(H2O)(lit.)'] |
pKa | pK1: 7.62(+1) (20°C,μ=0.01) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.7080 (estimate) |
MDL | MFCD00024137 |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
application | 1-amino isoquinoline can be used as an intermediate in pharmaceutical synthesis, and can be used in laboratory research and development and chemical pharmaceutical synthesis. |
preparation | add 12.40g (0.32mol) sodium amide powder and 300 ml m-xylene into a 500 ml three-neck flask, stir at 120 ℃ and dissolve 10.32g (0.08mol) isoquinoline in 100 ml m-xylene into a three-neck flask drop by drop, continue stirring for 4 hours after dropping. After the reaction is completed, m-xylene is evaporated, the remaining residue is dissolved in hot water, and the crystallization product 1-amino isoquinoline is 6.90g (0.048mol), the yield is 60%, and the melting range is 120~121 ℃. |