Name | parbendazole |
Synonyms | pbdz helmatac parbendazole PARBENDAZOLE methyl5-butyl-2-benzimidazolecarbamate 5-butyl-2-benzimidazolecarbamicacimethylester methyl (6-butyl-1H-benzimidazol-2-yl)carbamate n-(butyl-5,benzimidazolyl)-2,carbamatedemethyle methyl N-(5-butyl-3H-benzoimidazol-2-yl)carbamate (5-butyl-1h-benzimidazol-2-yl)-carbamicacimethylester (4-butyl-1h-benzimidazol-2-yl)-carbamicacidmethylester |
CAS | 14255-87-9 |
EINECS | 238-133-3 |
InChI | InChI=1/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17) |
InChIKey | YRWLZFXJFBZBEY-UHFFFAOYSA-N |
Molecular Formula | C13H17N3O2 |
Molar Mass | 247.29 |
Density | 1.1214 (rough estimate) |
Melting Point | 255-257°C |
Boling Point | 390.33°C (rough estimate) |
Solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) |
Appearance | Solid |
Color | White to Off-White |
pKa | 11.66±0.10(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
Stability | Stable. Incompatible with strong oxidizing agents. |
Refractive Index | 1.5700 (estimate) |
In vitro study | Parbendazole is a tubulin destabilizer, with an EC 50 of 530 nM, and can induce DNA damage. Parbendazole (2-10 μM) inhibits the assembly of microtubules dose-dependently, with an IC 50 of 3 μM. Parbendazole (2-20 μM)-treated cells show an complete absence of microtubules in Vero cells. Parbendazole (up to 10 μM) inhibits the growth of CLd-AXE myxamoebae. Parbendazole (2-5 μM) potently inhibits tubulin purified from the wild-type myxamoebae. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R63 - Possible risk of harm to the unborn child R22 - Harmful if swallowed |
Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
WGK Germany | 3 |
RTECS | DD6495000 |
HS Code | 2933997500 |
Toxicity | LD50 in mice, rats (g/kg): >4 orally, both species (Actor) |