Molecular Formula | C186H286N50O62S |
Molar Mass | 4244.60796 |
Melting Point | >209°C (dec.) |
Solubility | Acetonitrile (Slightly), Water (Slightly) |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | Refrigerator, under inert atmosphere |
Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents. |
Use | Treatment of type 2 diabetes mellitus
Anti-HIV drugs |
In vitro study | A cell-cell fusion assay reveals that the effective concentration for achieving 50% inhibition (IC 50 ) of Enfuvirtide is 23 ± 6 nM. IFN-λs (1, 2, or 3) or the antiretrovirals (AZT, Efavirenz, Indinavir, and Enfuvirtide) significantly inhibita the expression of HIV p24 antigen and Gag gene in macrophages. IFN-λs (1, 2, or 3) also enhanced the anti-HIV (Bal) effect of AZT, Efavirenz, Indinavir, and Enfuvirtide. |
In vivo study | Enfuvirtide has a T 1/2 of 3.8 h. |