Molecular Formula | C34H56N10O9 |
Molar Mass | 748.87 |
Water Solubility | Soluble in water at 1mg/ml |
Solubility | TFA 0.1%: soluble |
Storage Condition | -20°C |
Physical and Chemical Properties | Solubility: TFA 0.1%: soluble storage conditions:? 20℃ WGK Germany:3 |
In vitro study | TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1. TRAP-6 (0.01-10 μM; 30 min) activates human platelets. TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane. |
In vivo study | TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats. |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.335 ml | 6.677 ml | 13.353 ml |
5 mM | 0.267 ml | 1.335 ml | 2.671 ml |
10 mM | 0.134 ml | 0.668 ml | 1.335 ml |
5 mM | 0.027 ml | 0.134 ml | 0.267 ml |
biological activity | TRAP-6 (PAR-1 agonist peptide), a polypeptide fragment that is a selective protease-activated receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via thrombin receptors. TRAP-6 was inactive for PAR4. |
target | PAR1 |
in vitro study | TRAP-6 (0.01-10 μ m) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1. TRAP-6 (0.01-10 μ m; 30 min) activates human platelets. TRAP-6 (100 μ m) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane. |
in vivo study | TRAP (1 mg/kg; I. v.) produces a biphasic response in blood pressure in inactin-anesthetized rats. |