141043-16-5 - Names and Identifiers
Name | (3R)-(+)-3-(TRIFLUOROACETAMIDO)PYRROLIDINE HYDROCHLORIDE
|
Synonyms | (R)-3-(Trifluoroacetamido)pyrrolidine HCl (3R)-(+)-3-(Trifluoroacetamido)pyrrolidineHCl (R)-3-(Trifluoroacetamido)pyrrolidine hydrochloride 2,2,2-trifluoro-N-((R)-pyrrolidin-3-yl)acetamide HCl (3R)-(+)-3-(TRIFLUOROACETAMIDO)PYRROLIDINE HYDROCHLORIDE (R)-2,2,2-Trifluoro-N-(pyrrolidin-3-yl)acetaMide hydrochloride 2,2,2-trifluoro-N-[(3R)-pyrrolidin-3-yl]acetamide hydrochloride
|
CAS | 141043-16-5
|
InChI | InChI=1/C6H9F3N2O.ClH/c7-6(8,9)5(12)11-4-1-2-10-3-4;/h4,10H,1-3H2,(H,11,12);1H/t4-;/m1./s1 |
141043-16-5 - Physico-chemical Properties
Molecular Formula | C6H10ClF3N2O
|
Molar Mass | 218.6 |
Melting Point | 235°C |
Boling Point | 277.8°C at 760 mmHg |
Flash Point | 121.8°C |
Water Solubility | almost transparency |
Vapor Presure | 0.00341mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Almost white |
Storage Condition | Room Temprature |
MDL | MFCD02094762 |
141043-16-5 - Introduction
(3R)-(+)-3-(trifluoroacetamido) pyrrolidine hydrochloride, also known as Rivanicline hydrochloride, is a pharmaceutical compound. The following is an introduction to its nature, use, formulation and safety information:
Nature:
-Appearance: White to slightly yellow crystalline powder
-Molecular formula: C7H6ClF3N2O
-Molecular weight: 232.58g/mol
-melting point: 158-163 ℃
-Solubility: Soluble in water and some organic solvents, such as methanol and dimethyl sulfoxide
Use:
(3R)-( )-3-(trifluoroacetamido) pyrrolidine hydrochloride is mainly used as an adjunctive therapeutic drug for nicotine addiction. It can be used to help reduce nicotine withdrawal symptoms and promote smoking cessation. By binding to nicotine receptors, it reduces the stimulating effect of nicotine on the brain and reduces the desire to smoke.
Preparation Method:
(3R)-( )-3-(trifluoroacetamido) pyrrolidine hydrochloride can be prepared by chemical synthesis. A common synthetic method is to react pyrrolidine with trifluoroacetamide to produce (3R)-3-(trifluoroacetamido) pyrrolidine, which is then reacted with hydrochloric acid to give the hydrochloride form.
Safety Information:
-When using or handling (3R)-( )-3-(trifluoroacetamido) pyrrolidine hydrochloride, the relevant safety procedures should be observed.
-It should be stored in a dry, cool place, away from fire and oxidizing agents.
-Wear appropriate personal protective equipment, such as lab gloves and goggles.
-avoid skin contact and inhalation of dust, such as inadvertent contact, should immediately rinse with plenty of water.
-In case of discomfort or ingestion, seek medical attention immediately and provide relevant information to the doctor.
Please note that the above information is for informational purposes only and that standard procedures and safety guidelines for preparation and disposal should be followed for use and handling.
Last Update:2024-04-09 15:17:52