Molecular Formula | C46H77NO17 |
Molar Mass | 916.1 |
Density | 1.1424 (rough estimate) |
Melting Point | 135-137°C |
Boling Point | 796.05°C (rough estimate) |
Specific Rotation(α) | D25 -46° (c = 2 in methanol) |
Flash Point | 546.9°C |
Water Solubility | H2O: soluble 50 mg/mL |
Vapor Presure | 0mmHg at 25°C |
pKa | pKa 7.73(H2Ot = 25I = 0.167) (Uncertain) |
Storage Condition | Sealed in dry,2-8°C |
Stability | Solutions are stable at pH 4-9 (most stable at pH 7); Below pH 4 tylosin B (desmycosin) is formed as a result of acid hydrolysis; In neutral and alkaline pH – tylosin aldol (TAD) is formed toget |
Refractive Index | 1.5280 (estimate) |
MDL | MFCD09881413 |
Use | Used as an antibacterial |
In vitro study | Tylosin exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit . Tylosin also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmA I , respectively. |
Risk Codes | R42/43 - May cause sensitization by inhalation and skin contact. R50 - Very Toxic to aquatic organisms |
Safety Description | S36 - Wear suitable protective clothing. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S22 - Do not breathe dust. |
HS Code | 2941906000 |
Toxicity | Tylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog. |
Downstream Products | Cefepime hydrochloride |