Name | semustine |
Synonyms | icig1110 semustine SEMUSTINE ICIG 1110 1-(2-chloroethyl)-1-formyl-3-(4-methylcyclohexyl)urea 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-ure N-[2-CHLOROETHYL]-N'-[4-METHYLCYCLOHEXYL]-N-NITROSOUREA 1-(2-Chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea 1-(2-Chloroethyl)-3-(trans-4-methyl-cyclohexyl)-1-nitrosourea 1-(2-Chloroethyl)-1-([(4-methylcyclohexyl)amino]carbonyl)-2-oxohydrazine |
CAS | 13909-09-6 |
InChI | InChI=1/C11H19ClN2O2/c1-9-2-4-10(5-3-9)13-11(16)14(8-15)7-6-12/h8-10H,2-7H2,1H3,(H,13,16) |
Molecular Formula | C10H18ClN3O2 |
Molar Mass | 247.72 |
Density | 1.3346 (rough estimate) |
Melting Point | 64°C (rough estimate) |
pKa | 10.89±0.40(Predicted) |
Storage Condition | Room Temprature |
Refractive Index | 1.5500 (estimate) |
Hazard Symbols | T - Toxic |
Risk Codes | R45 - May cause cancer R46 - May cause heritable genetic damage R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | 3249 |
WGK Germany | 3 |
RTECS | YS5000000 |
Hazard Class | 6.1(a) |
Packing Group | II |
This product is l-(2-chloroethyl)-3-(4-methylcyclohexyl)-l-nitrosourea. The content of C10H18C1N302 shall be between 97.0% and 103.0% based on the dry product.
The melting point of this product (General 0612) is 71~75°C.
take 0.25g of this product, add water 20ml, shake, filter, filter residue is washed with water 10ml, combined wash and filtrate, according to law inspection (General rule 0801), not more concentrated (0.02%) than the control solution made from of standard sodium chloride solution.
operation in the dark. Take this product, add ethanol to dissolve and make a solution containing lOmg per lml, as a test solution; Take an appropriate amount of precision, and quantitatively dilute with ethanol to contain 0.1 mg solution, as a control solution. According to the thin layer chromatography (General 0502) test, absorb 10 u1 of each of the above two solutions, respectively point on the same silica gel HF254 thin layer plate, with chloroform-cyclohexane (3:1) as the developing solvent, expand, dry, and put under UV light (254mn). Test solution such as impurity spots, compared with the control solution of the main spot, not deeper. In the case of re-placing iodine vapor, the origin should not be yellow.
take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure for 4 hours. The weight loss shall not exceed 0.5% (General rule 0831).
not more than 0.1% (General rule 0841).
operation in the dark. Take this product, precision weighing, add cyclohexane to make a solution containing about 20ug per lml, according to UV-visible spectrophotometry (General rule 0401), measure absorbance at the wavelength of 232nm, it is obtained by calculating the absorption coefficient of C10H18C1N302 as 254.
antineoplastic agents.
shading, sealing, storage in cold place.
This product contains semustine (C10H18C1N302) should be 90.0% to 110.0% of the label.
should comply with the relevant provisions under the capsule (General rule 0103).
operation in the dark. Take the contents under the difference of loading amount, mix them evenly, weigh an appropriate amount (about 25mg of semustine) precisely, and place them in a 50ml measuring flask, add appropriate amount of cyclohexane, shake to dissolve and dilute semustine to the scale, shake well, filter, take 2ml of continued filtrate precisely, put it in 50ml measuring flask, dilute it to the scale with cyclohexane, shake, according to the method under the content determination of semustine, obtained.
Same as smustine.
(l)10mg (2)50mg
shading, sealing, storage in cold place.