1354021-09-2 - Names and Identifiers
1354021-09-2 - Physico-chemical Properties
Molecular Formula | C5H4BrClN2
|
Molar Mass | 207.46 |
Density | 1.834±0.06 g/cm3(Predicted) |
Boling Point | 299.2±35.0 °C(Predicted) |
pKa | 2.52±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
1354021-09-2 - Introduction
2-Chloro-3-amino-4-bromopyridine (2-Chloro-3-aminopyridine) is an organic compound with the chemical formula C5H5ClBrN2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2-Chloro-3-amino-4-bromopyridine is a white to light yellow solid.
-Solubility: It is soluble in some organic solvents, such as alcohols and ether solvents, but difficult to dissolve in water.
-Melting point: Its melting point is about 80-82°C.
-Stability: It is relatively stable under conventional storage and use conditions.
Use:
-2-Chloro-3-amino-4-bromopyridine is a commonly used intermediate compound, which is widely used in organic synthesis and drug research and development.
-It can be used to prepare a variety of biologically active molecules, such as drugs, pesticides and dyes.
-It can also be used as a catalyst and ligand for organic synthesis reactions.
Preparation Method:
There are many preparation methods for 2-chloro-3-amino-4-bromopyridine. The following is a commonly used synthetic route:
1. first, 2-bromo -3-amino -4-formyl pyridine and thionyl chloride react to generate 2-bromo -3-amino -4-formyl sulfoxide.
2. The product was reacted with alkaline copper chloride solution to obtain 2-bromo-3-amino-4-bromopyridine.
3. Finally, the obtained 2-bromo-3-amino-4-bromopyridine is reacted with sodium chloride in the presence of hydrochloric acid to obtain 2-chloro-3-amino-4-bromopyridine.
Safety Information:
-2-Chloro-3-amino-4-bromopyridine has a stimulating effect on the eyes, skin and respiratory tract, and protective measures should be paid attention to when using.
-When handling and using, follow safe operating procedures and use appropriate personal protective equipment, such as gloves and masks.
-Avoid inhaling the dust or gas of the compound. If ingestion, inhalation or skin contact occurs, seek medical attention immediately.
-The storage of this compound should avoid contact with flammable materials, and the storage temperature should generally be at room temperature.
Please note that for any chemical, please carefully read and follow its relevant safety data sheet before use, and use it in accordance with appropriate operating procedures.
Last Update:2024-04-09 21:00:56