Dorzolamine-2-1 is a compound whose chemical formula is C10H14N2O. It is a white crystalline solid with a structure having a benzene ring and a pyrrole ring. Dorzolamide -2-1 is stable at room temperature but flammable. It is slightly soluble in water and has good solubility in organic solvents.
Dorzolamide -2-1 has antidepressant and sedative pharmacological activities, and is widely used in the field of medicine. As a derivative, it can affect the transport of neurotransmitters, thus playing an antidepressant role.
The preparation method of dorzolame-2-1 is through the reaction of benzamide and amidopropanol, and hydrogenation is carried out under acidic conditions. This preparation method is a common synthetic route, which can efficiently prepare dorzolamide -2-1.