Name | Eprosartan |
Synonyms | CS-1951 Teveten Eprosartan EPROSARTAN SKF-108566J SKF-108566) Eporlosartan Eprosartan Mysylate 4-[2-Butyl-5-(2-carboxy-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-benzoic acid (E)-3-[2-Butyl-1-[(4-carboxyphenyl)-methyl]imidazol-5-l]-2-(2-thienylmethyl)-2-propenoic Acid ((E)-3-[2-Butyl-1-[(4-carboxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoic Acid 4-({2-butyl-5-[2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid 4-({2-butyl-5-[(1E)-2-carboxy-3-thiophen-2-ylprop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid (E)- α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-y1]methylene]2-thiophenepropanoic acid |
CAS | 133040-01-4 |
InChI | InChI=1/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29)/b18-12+ |
Molecular Formula | C23H24N2O4S |
Molar Mass | 424.51 |
Density | 1.26g/cm3 |
Melting Point | 250-253°C |
Boling Point | 660.6°C at 760 mmHg |
Flash Point | 353.3°C |
Solubility | Dichloromethane (Slightly), Methanol (Slightly) |
Vapor Presure | 2.37E-18mmHg at 25°C |
Appearance | Solid |
Color | Pale Yellow to Light Yellow |
Storage Condition | Sealed in dry,2-8°C |
Refractive Index | 1.627 |
Physical and Chemical Properties | Crystallization from methanol, melting point 260-261 °c. |
Use | Antihypertensive drugs. Imidazole acrylic angiotensin II receptor antagonists. For the treatment of high blood pressure. |
crystallized from methanol, melting point 260-261 °c.
2-n-butyl -5-formyl imidazole dissolved in ethyl acetate, add methyl acrylate at room temperature, then add 1,8-ammonia heterobicyclo [5,4.0] Deco =-7-ene reaction, the material obtained by the reaction is dissolved in toluene, (2-thienylmethyl) malonic acid monoethyl ester and piperidine are added, Reflux reaction under reduced pressure, the resulting material was dissolved in toluene, and methyl p-bromomethyl benzoate was added thereto, followed by stirring. The toluene is distilled off at less than 60-70 °c and the resulting material is heated at 95-100 °c until the reaction is complete and subjected to hydrolysis and work-up to give eprosartan.
Smith Kline beechamn, UK, was successfully developed in 1997. Solvay, the Netherlands, was licensed to be listed in the US in December 1999 and in the UK and Australia in 2000. Antihypertensive drugs. Benazol acrylic angiotensin II receptor antagonists. For the treatment of high blood pressure.