Name | Mordant Red 3 |
Synonyms | CI 58005 C.I. 58005 CI NO 58005 Alizarin red Mordant Red 3 DIAMOND RED W Alizarin Red S Alazarin red s. C.I.Mordant Red 3 C.I. Mordant Red 3 Acid Chrome Red S-80 Acid Mordant Red S-80 ALIZARINSODIUMSULPHATE LABOTEST-BB LT00159822 ALIZARINSODIUMSULPHONATE Sodium alizarinesulfonate Alizarine Red S (C.I. 58005) Alizarin Red S, certified, pure ALIZARIN SULFONIC ACID SODIUM SALT dihydroxyanthraquinone-sulfonic acid sodium salt 3,4-DIHYDROXY-2-ANTHRAQUINONESULFONIC ACID, SODIUM SALT 3,4-DIHYDROXY-9,10-DIOXO-2-ANTHRACENESULFONIC ACID, SODIUM SALT sodium 3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate 9,10-DIHYDRO-3,4-DIHYDROXY-9,10-DIOXO-2-ANTHRACENESULFONIC ACID, SODIUM SALT |
CAS | 130-22-3 |
EINECS | 204-981-8 |
InChI | InChI=1/C14H8O7S.Na.H2O/c15-11-6-3-1-2-4-7(6)12(16)10-8(11)5-9(22(19,20)21)13(17)14(10)18;;/h1-5,17-18H,(H,19,20,21);;1H2/q;+1;/p-1 |
InChIKey | HFVAFDPGUJEFBQ-UHFFFAOYSA-M |
Molecular Formula | C14H7NaO7S |
Molar Mass | 342.26 |
Melting Point | >250°C |
Boling Point | 287-289°C |
Water Solubility | Soluble in water and alcohol. |
Solubility | H2O: soluble1mg/mL |
Appearance | Powder |
Color | Various |
Maximum wavelength(λmax) | ['556nm, 596nm, 423nm, 546nm'] |
Merck | 14,8573 |
BRN | 4117090 |
pKa | 4.5, 11(at 25℃) |
Storage Condition | room temp |
Stability | Stable. Incompatible with strong oxidizing agents. |
MDL | MFCD00013049 |
Use | Commonly used in coarse spinning, worsted, carpet, carpet are used for color matching |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | CB1095300 |
TSCA | Yes |
HS Code | 32049090 |
Reference Show more | 1. Wu Bo Liu Ye Ma Xu et al. Study on the effect of 3D printed collagen/hydroxyapatite scaffold on osteogenic differentiation of bone marrow mesenchymal stem cells [J]. Chinese Journal of Geriatric Orthopedics and Rehabilitation Electronics 2020 v.6(03):7-11. 2. Yu Xiaohua, Liu Shutai, Dong Kai, et al. Effect of P38MAPK Signal Pathway Inhibitor SB203580 on MC3T3-E1 Proliferation and Differentiation of Osteoblasts under High Glucose [J]. Journal of Practical Stomatology 2015 000(002):184-187. 3. Yu Haili, Dong Kai, Liu Zhonghao. Experimental Study on Effects of Different Concentrations of Glucose on MC3T3-E1 Cells [J]. Stomatology Research 2014 30(08):717-721. 4. Chen Tao Gao Pan Wang Yanwei et al. Experimental Study on Effects of Different Concentrations of High Glucose on MG-63 Cells [J]. Chinese Journal of Oral Implant 2015 v.20(04):155-157. 5. Chen Wuyue, Chen Ying, Luan Huiling, et al. Antioxidant Activity of Erzhi Pill and Its Effect on Osteoporosis Inhibition of Zebrafish [J]. Strait Pharmaceutical 2017(29):12-15. 6. Xu Jingjing, Lei Lei, Luo Ziyuan, the effect of platelet-rich fibrin on proliferation and osteogenic ability of human periodontal ligament cells [J]. Journal of Jinan University (Natural Science and Medicine Edition), 2016(37):128-134. 7. Dong Kai. Experimental study on the effect of platelet-rich fibrin extract on osteoblasts [D]. Binzhou Medical College, 2013. 8. Xu Jingjing, Luo Ziyuan, Lei Lei Lei, etc. Effects of platelet-rich fibrin extract on human periodontal ligament cells stimulated by TNF-α [J]. Journal of Practical Stomatology, 2017, 02(v.33;No.163):95-100. 9. Zhang Fan, Si Wenteng, Bai Yu, Zou Shiping. Effect of naringin on osteogenic differentiation of human umbilical cord mesenchymal stem cells [J]. Rheumatism and Arthritis, 2016,5(05):9-12. 10. Liu Lin, Dong Kai, Liu Zhonghao. Experimental study on the effect of concentrated growth factor extract on MC3T3-E1 cells. Journal of Practical Stomatology. 11. Zhao Bingjie, Zhang Li, Yuan Jiarui, et al. Study on the effect of icariin on UMR-106 cells and osteoporotic zebrafish [J]. Chinese herbal medicine, 2016(47):3441-3446. 12. Tu Yan, Xiong Lina, Liu Xiangjie, et al. Study on the Effect of Icariin on Osteogenic Differentiation of Osteoblasts and the Relationship between Wnt/-catenin Signal System [J]. Chinese Traditional Chinese Medicine Emergency, 2017, 26(003):448-450. 13. Ling Jie, Wang Mo, Wang Dandan, et al. Chromatographic capture combined with zebrafish model for efficient screening of anti-osteoporosis active components of psoralea corylifolia [J]. Chinese Journal of Pharmacy, 2018, 053(012):956-961. 14. Dong Kai, Hao Pengjie, Zhou Wenjuan, et al. Effect of hyperbaric oxygen on proliferation and differentiation of osteoblasts under high glucose [J]. Chinese Journal of Oral Implant, 2018, 023(003):105-108. 15. Teng Teng, Sun Xin, Zhang Ran, et al. Effect of Astragalus Polysaccharide on Activity of MC3 T3-E1 Cells in High Glucose Environment [J]. Journal of Dental Pulp and Periodontology, 2015, 000(006):348-353. 16. Duan, Lian, et al. "Magnetic Targeting of HU-MSCs in the Treatment of Glucocorticoid-Associated Osteonecrosis of the Femoral Head Through Akt/Bcl2/Bad/Caspase-3 Pathway." International journal of nanomedicine 15 (2020): 3605.https://dx.doi.org/10.2147% 2FIJ 17. Li, Yutong, et al. "Involvement of bone morphogenetic protein-related pathways in the effect of aucubin on the promotion of osteoblast differentiation in MG63 cells." Chemico-biological interactions 283 (2018): 51-58.https:// doi.org/10.1016/j.cbi. 2018.02.0 18. [IF = 1.82] Wen Jiang et al."Preparation of viscose fiber modified with silkworm pupa chitosan oligosaccharide by β-glucosaccharase:." Text Res J. 2019;89(21-22):4461-4475 19. [IF = 9.078] Xianrui Xie et al."A woven scaffold with continuous mineral gradients for tendon-to-bone tissue engineering." Compos Part B- Eng. 2021 May;212:108679 20. [IF = 6.4] Meichen Liu et al."Fe3O4 @ Polydopamine-Labeled MSCs Targeting the Spinal Cord to Treat Neuropathic Pain Under the Guidance of a Magnetic Field." Int J Nanomed. 2021; 16: 3275-3292 21. [IF = 5.115] Lian Duan et al."Magnetic Targeting of HU-MSCs in the Treatment of Glucocorticoid-Associated Osteonecrosis of the Femoral Head Through Akt/Bcl2/Bad/Caspase-3 Pathway." Int J Nanomed. 2020; 15: 3605-3620 22. [IF = 3.932] Yaofeng Xu et al."Activation of the extracellular-signal-regulated kinase (ERK)/c-Jun N-terminal kinase (JNK) signal pathway and osteogenic factors in subchondral bone of patients with knee osteoarthritis." Ann Transl Med. 2021 Apr; 9(8): 663 23. [IF = 2.691] Yiqi Zhang et al."Arbutin ameliorates glucocorticoid-induced osteoporosis through activating autophagy in osteoblasts:." Exp Biol Med. 2021;246(14):1650-1659 24. [IF = 8.718] Han Hui et al."The miR-98-3p/JAG1/Notch1 axis mediates the multigenerational inheritance of osteopenia used by maternal dexamethasone exposure in female rat offspring." Exp Mol Med. 2022 Mar;54(3):298-308 25. [IF = 6.321] Guangqu Liu et al."Multivesicular Liposomes for Glucose-Responsive Insulin Delivery." Pharmaceutics. 2022 Jan;14(1):21 26. [IF = 7.46] Rui Liu et al."Visual classification for sesame oil adulteration detection and quantification of compounds used as adulterants using flavor compounds targeted array sensor in combination with DD-SIMCA and PLS." Sensor Actuat B- Chem. 2022 Apr;357:131335 note: our company can only provide some information for some products, and our company does not guarantee the authority of the information provided, for customer reference and exchange research only. Purpose: Determination of fluoride. Acid-base indicator, pH3 · 7 (yellow)-5 · 2 (purple). It can form colored compounds with many metal ions for the color reaction and colorimetric determination of zirconium, thorium, aluminum, titanium and beryllium. storage condition: RT sensitivity: easy to absorb moisture appearance: orange yellow or yellow brown powder soluble in water, slightly soluble in ethanol, insoluble in benzene and chloroform. The pH of 1% aqueous solution is 2 · 15, and its aqueous solution is light yellowish brown. It turns yellow after adding hydrochloric acid, and turns blue-purple after adding sodium hydroxide. It's irritating. |
color index | 58005 |
pH indicator color change ph range | 4.3(yellow)-6.3(violet) |
main applications | Nanocomposite material, chemical mechanical polishing, optical fibers, display device, carbon nanotubes, textiles, determination of aluminum,iron,copper,manganese,zinc,calcium,magnesium,zirconium,hafnium,molybdenum,uranium,vanadium, detergents, hair dyes, determination of proteins,clotrimazole,ketoconazole,piroxicam,and tenoxicam |
biological field application | Detecting Candida,lactic acid bacteria,microorganisms; treating gastropathy,viral diseases |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
history of use | In 1869, German chemists Karl Grebe and Karl Rieberman extracted anthracene from coal tar, which was then oxidized to anthraquinone, and then alkali melted into alizarin red. In this way, alizarin red became the first artificially synthesized natural dye. Its advent brought a huge impact on traditional vegetable dyes, alizarin red, which can be produced on a large scale and is cheap, suddenly meets the growing commercial demand, making the demand for natural alizarin red plummet. At that time, large tracts of European madder fields in France could only be converted to other crops. Today, alizarin red is still used as a dye on fabrics, but under the influence of other artificial dyes, its prosperity is not as good as before. Alizarin red extracted from the roots of Rubiaceae in Europe was previously used as a food additive pigment, but it was banned by Japan, European and American countries because of the carcinogenic risk found in research. At present, the commercial alizarin red is mostly used to dye fabrics, and it is also made into "madder lake" painting pigments. Of course, if you are a biological Wang, you may be more familiar with the so-called "osteoblast alizarin red dyeing experiment". |
preparation | a method for preparing water-soluble alizarin red s, the steps are as follows: (1) in a 10000ml three-mouth flask, 2500g of fuming sulfuric acid (20% SO3 by weight) is added, 1000g of alizarin powder is added while stirring at normal temperature, and the reaction temperature is raised to 42 ℃, heating at 110 ℃ for 4-5h, after the reaction is completed; (2) add the reaction product to 10L of water, filter the generated precipitate (trace amount), add sodium chloride to the filtrate at 40 ℃, salting out, cooling, leaving overnight, filtering, washing with 1000ml of 10% sodium chloride aqueous solution to obtain 4050g paste. (3) then remove the salt and other impurities, with ethanol, ether wash, dry alizarin red S. |
toxicity | alizarin red S concentration is 400 mg/L, the 96 h mortality rate is 0; When alizarin red concentration is 900 mg/L, all died at 72 h; the semi-lethal concentrations of alizarin red S for 24, 48, 72 and 96 h of juvenile flatfish were 788, 718, 651 and 618 mg/L respectively, and the safe mass concentration was 179 mg/L. This shows that alizarin red S has low toxicity to juvenile snout fish and is suitable for its label release. In actual work, it is recommended to use the concentration of 179~400 mg/L as the marker, and on the basis of ensuring the survival rate, a better marker effect is obtained. |
use | commonly used in carpets, worsted carpets and blankets for color matching biochemical research alizarin red S is also called sodium alizarin flavin, which is soluble in hot water and ethanol, insoluble in benzene and carbon tetrachloride, and has a pH value of 3.7?5.2. It turns reddish brown with yellow. Yellow needle-like crystals or powder, the aqueous solution is yellowish brown, orange after adding hydrochloric acid, adding sodium hydroxide to become blue, dissolved in ammonia solution is purple, mainly as an acid-base indicator. determination of fluoride; Acid-base indicator, pH3.7 (yellow) ~ 5.2 (purple); It can generate colored compounds with many metal ions for color reaction and colorimetric determination of zirconium, thorium, aluminum, titanium and beryllium. Microscopic staining agent, in vivo staining of nerve tissue, chromosome staining in plant cytology and reagent for verification of belladonna |