Molecular Formula | C27H46N2O3 |
Molar Mass | 446.67 |
Density | 1.163 |
Melting Point | >210°C (dec.) |
Boling Point | 565.4±50.0 °C(Predicted) |
Flash Point | 295.7°C |
Solubility | Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated) |
Vapor Presure | 0Pa at 25℃ |
Appearance | Solid |
Color | White to Off-White |
pKa | 14.69±0.70(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.574 |
LogP | 4.6 at 22℃ and pH12 |
overview | rocuronium bromide (Rocuroniumbromide) is a single quaternary ammonium steroid medium-effect muscle relaxants, developed by the Dutch Organon company, and first listed in the United States in 1994. As an auxiliary drug for anesthesia, this product is used for tracheal intubation during anesthesia and muscle relaxation during surgery. It has the characteristics of fast onset, short duration, rapid recovery, no tachycardia and blood pressure changes, and no histamine release. 3 α,17 β-(dihydroxy)-2 β-(morpholin-1-yl)-16-(pyrrolidin-1-yl)-5 α-androstane is an intermediate in the synthesis of rocuronium. |
use | (2b,3a,5a,16b,17b)-2-(4-morpholinyl)-16-(1-pyrrolidine) androstane -3,17-diol is an alcohol derivative and can be used as an intermediate of rocuronium bromide. |