Molecular Formula | C25H28N6O7S3 |
Molar Mass | 620.72 |
Density | 1.55±0.1 g/cm3(Predicted) |
Melting Point | 207-209°C |
Specific Rotation(α) | D20 -48.5° (c = 0.5 in methanol) |
Solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Heated) |
Appearance | Solid |
Color | Off-White to Pale Yellow |
Merck | 14,1921 |
pKa | 8.08±0.60(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
Refractive Index | 1.71 |
In vitro study | The MIC50/MIC90 of Cefditoren for Moraxella catarrhalis and Haemophilus influenzae were 0.12/0.5 and ≤ 0.008/0.015 mg/mL, respectively. Cefditoren (MIC(90), 0.5 mg/mL) was 4-to 128-fold more effective than other beta-lactams in the treatment of Diplococcus Pneumonia, and acting on beta-hemolytic streptococci is the most effective beta-lactam (including penicillin). Cefditoren (MIC(90),mg/mL/% susceptible) tested for Haemophilus influenzae (0.03/100) and Moraxella catarrhalis (0.06-0.5/100) the activity of is equivalent to Cefixime and is significantly higher than cefaclor. Cefditoren exhibited a T(1/2) of 200-2 hours, C(max) in terms of Cefditoren pharmacokinetics at doses of 400 or 1.5 mg pivoxil. Values were 2.8 and 4.6 mg/mL, respectively. Cefditoren has a broad spectrum of antibacterial activity against a number of clinically important β-lactamase resistant gram-positive and gram-negative species. Cefditoren is also effective against methicillin-susceptible S. Aureus strains. Cefditoren acts on most common isolated respiratory pathogens and is more effective than other orally administered antibiotics. Cefditoren up-regulated the expression levels of Mrp2,Bcrp and Oat2, and down-regulated P-gp and Oct 1 mRNA expression. |
RTECS | XI0367800 |