Name | Epmedin C |
Synonyms | Epmedin C EPIMEDIN C BAOHUOSIDE VI EPIMEDIN C(PRIMARY STANDARD) 7-(β-D-glucopyranosyloxy)-5-hydroxy-2- (4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)- 4H-1-Benzopyran-4-one,3-[[6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)- α-L-mannopyranosyl]oxy]- 3-{[6-deoxy-2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-mannopyranosyl]oxy}-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside 3-((6-Deoxy-2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-mannopyranosyl)oxy)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one |
CAS | 110642-44-9 |
InChI | InChI=1/C39H50O19/c1-14(2)6-11-19-21(54-38-32(50)29(47)26(44)22(13-40)55-38)12-20(41)23-27(45)35(33(56-34(19)23)17-7-9-18(51-5)10-8-17)57-39-36(30(48)25(43)16(4)53-39)58-37-31(49)28(46)24(42)15(3)52-37/h6-10,12,15-16,22,24-26,28-32,36-44,46-50H,11,13H2,1-5H3/t15-,16-,22+,24-,25-,26+,28+,29-,30+,31+,32+,36+,37-,38+,39-/m0/s1 |
Molecular Formula | C39 H50 O19 |
Molar Mass | 822.8 |
Density | 1.57±0.1 g/cm3(Predicted) |
Melting Point | 179-180 °C(Solv: methanol (67-56-1)) |
Boling Point | 1062.1±65.0 °C(Predicted) |
Flash Point | 322.2°C |
Solubility | DMSO : 250 mg/mL (303.84 mM; Need ultrasonic) |
Vapor Presure | 0mmHg at 25°C |
Appearance | Pale yellow square crystal |
Color | Yellow to Dark Yellow |
Maximum wavelength(λmax) | 313nm(EtOH)(lit.) |
pKa | 5.90±0.40(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.677 |
MDL | MFCD04039820 |
Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Wushan Epimedium. |
HS Code | 29329990 |
Reference Show more | 1. Wang Ying, Gao Xia, Chen Yan, et al. Effect of carbomer on enzymatic hydrolysis of total flavonoids from epimedium [J]. Chinese Journal of Experimental Formulas 2014 20(009):1-5. 2. Fan Xing, Yang Chengzi, Bao Xiaping, et al. Study on HPLC Fingerprint of Qigu Capsule [J]. Chinese Herbal Medicine, 2014, 045(009):1257-1261. 3. Wang Yingzhe, Jiang Dacheng, Rong Road, Zodiac Jing Lei, Zhang Qiang, Weng Lili. Comparative Analysis of Flavonoids in Epimedium Korea from Northeast China [J]. Journal of Pharmaceutical Analysis 2019 39(11):2034-2040. 4. Liu Cong Yan Gao Xia Chen Yan et al. Feasibility Study on Improving Oral Bioavailability of Total Flavonoids of Epimedium by Bionic Enzymatic Hydrolysis Enteric-coated Capsules [J]. China Journal of Pharmaceutical Industry 2016(9):1158-1164. 5. Li Jing, Wang Yingzhe, Liu Yucui, Jing Zhixian, Yan Li, Guo Junjie, Jiang Dacheng, Xiao Jinglei. Detection and Analysis of Effects of Geographical Environmental Factors on Spatial Distribution of Flavonoids in Epimedium Korea [J]. Chinese Journal of Traditional Chinese Medicine, 2019,44(24):5368-5374. 6. Zhang Yan. Separation and Purification of Epimedium EF5 Flavonoids by Macroporous Adsorption Resin [J]. Northern Pharmacy, 2015, 000(011):11-13. 7. Liu Congyan, Gao Xia, Huang Mengmeng, et al. Preparation and Evaluation of Epimedium Total Flavonoids Biomimetic Enzymatic Hydrolysis Enteric-coated Capsules [J]. Chinese Herbal Medicine, 2016(20). 8. Liu congyan, Gao Xia, Chen Yan, et al. pharmacokinetic behavior of total flavonoids of epimedium in osteoporotic rats [J]. Chinese patent medicine, 2017, 39(008):1595-1600. 9. Gao Xia, Liu Xuan, Chen Yan, et al. biotransformation process analysis of total flavonoids of epimedium [J]. Chinese journal of traditional Chinese medicine, 2013, 38(23):4079. 10. Gao Xia, Chen Yan, Wang Ying, et al. Effect of Dextrin Wet Granulation on Enzymatic Hydrolysis of Total Flavonoids from Epimedium [J]. Chinese Patent Medicine, 2014, 36(007):1392-1397. 11. Peng Jing, Ma Yihua, Chen Yan, et al. Simultaneous Biotransformation of Four Flavonoid Glycosides from Epimedium [J]. Chinese Patent Medicine, 2016, 38(9):1984-1990. 12. Yang Chengzi, Fan Xing, Bao Xiaping, et al. Simultaneous Determination of Five Components in Qigu Capsule by HPLC [J]. 2015 021(016):60-63. 13. Li Jing, Guo Junjie, Liu Yucui, Nian Minghui, Luan Hanyu, Li Ruotong, Xiao Jinglei. Study on Quantity-Quality Evaluation of Different Parts of Epimedium Korea Based on Colorimetry Principle [J]. Shi Zhen, Chinese Medicine, 2020,31(08):1895-1898. 14. Lan Hai, Liu Xinyan, Yu Ling, Monolan, Zhang Yan, Guo Ziyou, Wu Qing. Purification of epimedium and icariin by macroporous resin [J]. Chinese herbal medicine, 2020,51(17):4473-4481. 15. Xu Ting, Huang Mengmeng, Li Ruiyun, Yang Ru, Liu Lifang, Chen Yan. Study on Quality Evaluation of Different Parts of Multi-base Primary Epimedium [J]. Chinese herbal medicine, 2020,51(01):190-196. 16. Zhou, Yan-dan, et al. "Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway." Biomedicine & Pharmacotherapy 109 (2019): 2309-2317.https://doi.org/10.1016/j.biopha. 2018.11.108 17. Zhou, Jing, et al. "A strategy for rapid discovery of traceable chemical markers in herbal products using MZmine 2 data processing toolbox: A case of Jing Liqueur." Chinese Herbal Medicines (2021). 18. [IF=4.545] Yan-dan Zhou et al."Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway."Biomed Pharmacother. 2019 Jan;109:2309 19. [IF=4.411] Zhenxian Qin et al."A Widely Metabolomic Analysis Revealed Metabolic Alterations of Epimedium Pubescens Leaves at Different Growth Stages."Molecules. 2020 Jan;25(1):137 20. [IF=3.757] Congyan Liu et al."Enhanced hydrolysis and antitumor efficacy of Epimedium flavonoids mediated by immobilized snailase on silica."Process Biochem. 2019 Nov;86:80 21. [IF=5.34] Dong Shao et al."Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology."PHYTOMEDICINE. 2022 Jul;102:154177 |
use | chaohuodin c has the potential to treat cardiovascular diseases and bone loss. Sagittal Epimedium is a natural flavonoid extract used as a health product in traditional Chinese medicine. Chaohuodin C is used for administration before anesthesia to reduce gland secretion, tremor paralysis and motion sickness. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has a wide range of pharmacological effects such as anti-osteoporosis, anti-cancer, and immune enhancement. |
biological activity | Chaohuodin C (Epmedin C) is a natural compound that has a similar effect of estrogen in ovariectomized mice. |
chemical properties | yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Wushan epimedium. |