Name | Granisetron |
Synonyms | BRL 43694 BRL 43964 GRANESETRON GRANISETRON Granisetron Granisetron free base GRANISETRON(FREE BASE) 1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, endo- 1H-Indazole-3-carboxamide, 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]- |
CAS | 109889-09-0 |
EINECS | 686-533-5 |
InChI | InChI=1/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23) |
Molecular Formula | C18H24N4O |
Molar Mass | 312.41 |
Density | 1.33±0.1 g/cm3(Predicted) |
Boling Point | 532.0±40.0 °C(Predicted) |
pKa | 12.34±0.20(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Physical and Chemical Properties | White to yellowish white crystalline powder, odorless, soluble in water, difficult to dissolve in methanol, very difficult to dissolve in ethanol, almost insoluble in ether. Melting Point: 290-292 °c. |
HS Code | 2933399090 |
white or yellowish white crystalline powder, odorless. Soluble in water, more difficult to dissolve in methanol, very difficult to dissolve in ethanol, almost insoluble in ether. The melting point was 290-292 °c.
granisetron was obtained by reacting 1-methyl -1H-indazole -3-formyl chloride with 3-amino -9-methyl -9-azabicyclo [3.3.1] Nonane. Acidification with hydrogen chloride-glycolic acid gave granisetron hydrochloride.
developed by Smith Kline Beecham, USA, launched in 1991. Granisetron is a potent and highly selective 5-HT3 receptor antagonist of peripheral and central nervous system, and is one of the main anti Vomit drugs. It has a good preventive and therapeutic effect on Nausea and Vomit caused by radiotherapy, chemotherapy and surgery. Rapid onset, control of acute Vomit is better than ondansetron. For cytotoxic drugs or radiation induced Nausea and Vomit.