Name | Polaprezinc |
Synonyms | Z 103 Promac Polaprezinc POLAPREZINC ZINC CARNOSINE zinc l-carnosine complex b-Alanyl-L-histidinato Zinc zinc n-(3-aminopropionyl)histidine [b-Alanyl-kN-L-histidinato(2-)-kN,kO]-zinc zinc 2-[(3-azanidyl-1-oxido-propylidene)amino]-3-(3H-imidazol-4-yl)propanoate |
CAS | 107667-60-7 |
EINECS | 600-848-7 |
InChI | InChI=1/C9H14N4O3.Zn/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6;/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16);/q;+2 |
Molecular Formula | C9H12N4O3Zn |
Molar Mass | 289.61 |
Melting Point | >300°C |
Boling Point | 177.5°C |
Solubility | Aqueous Acid (Slightly) |
Appearance | White crystal |
Color | White to Off-White |
Storage Condition | Refrigerator |
In vivo study | Polaprezinc (PZ) is an antiulcer drug and a chelating compound consisting of a zinc ion, L-carnosine, a β-alanine dipeptide and L-histidine. Polaprezinc exerts antioxidant effects and scavenges free radicals. The efficacy of Polaprezinc is reported for acute radiation proctitis in an animal model and demonstrates that Polaprezinc has an anti-inflammatory effect following exposure to radiation. |
Toxicity | LD50 in male, female mice, rats (mg/kg): 220, 165, 405, 422 i.p.; 758, 874, >5000, >5000 s.c.; 1269, 1331, 8441, 7375 orally (Matsuda) |
Reference Show more | 1. [IF=6.4] Xue Gao et al."Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane."Int J Nanomed. 2022; 17: 17–29 |