Name | 1-bromo-3-methoxypropane |
Synonyms | 1-BroMo-3-Methoxypro 3-METHOXYPROPYLBROMIDE 1-bromo-3-methoxyproane 1-broMo-3-Methoxyproane 3-BROMO-1-METHOXYPROPANE 1-BROMO-3-METHOXYPROPANE 1-bromo-3-methoxypropane 3-Bromopropyl methyl ether Propane, 1-bromo-3-methoxy- |
CAS | 36865-41-5 |
InChI | InChI=1/C4H9BrO/c1-6-4-2-3-5/h2-4H2,1H3 |
InChIKey | CEVMYGZHEJSOHZ-UHFFFAOYSA-N |
Molecular Formula | C4H9BrO |
Molar Mass | 153.02 |
Density | 1.36 g/cm3 |
Boling Point | 132°C |
Flash Point | 30.6°C |
Vapor Presure | 37.2mmHg at 25°C |
Appearance | clear liquid |
Color | Colorless to Light yellow |
PH | 6-7 (H2O) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.4450-1.4490 |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
UN IDs | 2344 |
HS Code | 29033990 |
Hazard Class | IRRITANT |
Packing Group | Ⅲ |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
Introduction | 3-bromopropyl methyl ether is colorless-extremely light transparent yellow liquid at room temperature and pressure. It is a commonly used alkylation reagent, and it is also a key synthetic intermediate of brinzolamide, a drug molecule for the treatment of ocular hypertension and open-angle glaucoma. |
use | 3-bromopropyl methyl ether can be used as an intermediate in pharmaceutical chemistry and organic synthesis, for example, it is involved in the preparation of small molecule brinzolamide. Brinzolamide eye drops is currently a good drug for the treatment of ocular hypertension and the relief of elevated intraocular pressure in patients with open-angle glaucoma. In organic synthesis, the easy-to-leave nature of bromine units is mainly used as alkylating reagents to protect oxygen or nitrogen atoms. |
preparation method | 40g(0.2mol) of 1,3-dibromopropane is added to 50ml of methanol, sodium methoxide (methanol solution) is added, reflux reaction is carried out for 6 hours, 100ml of water is added and stirred, extracted with n-pentane and dried with anhydrous sodium sulfate, after filtration, n-pentane solvent is distilled, 30g of crude 1-methoxy-3-bromopropane was obtained, which is a colorless oil. Fig. 3-synthesis route of bromopropyl methyl ether |