1-acetyl-5-bromo-7-nitroindoline - Names and Identifiers
1-acetyl-5-bromo-7-nitroindoline - Physico-chemical Properties
Molecular Formula | C10H9BrN2O3
|
Molar Mass | 285.09 |
Density | 1.688±0.06 g/cm3(Predicted) |
Melting Point | 196-198°C |
Boling Point | 482.8±45.0 °C(Predicted) |
Flash Point | 245.8°C |
Vapor Presure | 1.78E-09mmHg at 25°C |
BRN | 237670 |
pKa | -2.90±0.20(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.639 |
MDL | MFCD00056018 |
1-acetyl-5-bromo-7-nitroindoline - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Risk Codes | 22 - Harmful if swallowed
|
Safety Description | 36/37 - Wear suitable protective clothing and gloves.
|
WGK Germany | 3 |
Packing Group | III |
1-acetyl-5-bromo-7-nitroindoline - Introduction
It belongs to an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White or light yellow crystal
-Molecular formula: C11H7BrN2O3
-Molecular weight: 299.09g/mol
-Melting point: about 152-154°C
-Boiling point: about 392.5°C
-Solubility: slightly soluble in water, soluble in most organic solvents
Use:
It is mainly used in organic synthesis reactions and chemical research, especially as an intermediate in drug development. The specific structure and function of this compound make it have potential application value in the field of medicine.
Preparation Method:
Synthesis is usually carried out by the following steps:
1. First, 2-bromo-5-nitroaniline is prepared by heating dibromobenzene (1,4-dibromobenzene) and nitric acid in a solvent.
2. Next, 2-bromo-5-nitroaniline and indole are reacted to produce 5-bromo-7-nitroindole.
3. Finally, 5-bromo-7-nitroindole is reacted by acidification of acetic anhydride to make a pill.
Safety Information:
The relevant safety information has not been made public, so further research is needed to carefully evaluate its potential risks to human health and the environment. When performing laboratory operations, personal protective measures should be observed, including wearing appropriate protective gloves, glasses and laboratory coats. In all cases, direct contact with skin and eyes should be avoided, and inhalation or ingestion of the compound should be avoided. If you are exposed or unwell, you should seek medical assistance immediately.
Last Update:2024-04-09 21:01:54