1-Piperidinecarboxylicacid, 4-(aminoiminomethyl)-, 1,1-dimethylethyl ester
tert-Butyl 4-amidinopiperidine-1-carboxylate
CAS: 885270-23-5
Molecular Formula: C11H21N3O2
1-Piperidinecarboxylicacid, 4-(aminoiminomethyl)-, 1,1-dimethylethyl ester - Names and Identifiers
| Name | tert-Butyl 4-amidinopiperidine-1-carboxylate |
| Synonyms | 1-Boc-4-piperidinamidine 1-Boc-4-AMidinopiperidine 1-Boc-4- carbamimidoylpiperidine tert-butyl 4-amidinopiperidine-1-carboxylate tert-Butyl 4-amidinopiperidine-1-carboxylate 4-carbamimidoyl-1-piperidinecarboxylic acid tert-butyl ester 1-Piperidinecarboxylicacid, 4-(aminoiminomethyl)-, 1,1-dimethylethyl ester 1-Piperidinecarboxylic acid, 4-(aMinoiMinoMethyl)-, 1,1-diMethylethyl ester |
| CAS | 885270-23-5 |
| InChI | InChI=1S/C11H21N3O2/c1-11(2,3)16-10(15)14-6-4-8(5-7-14)9(12)13/h8H,4-7H2,1-3H3,(H3,12,13) |
1-Piperidinecarboxylicacid, 4-(aminoiminomethyl)-, 1,1-dimethylethyl ester - Physico-chemical Properties
| Molecular Formula | C11H21N3O2 |
| Molar Mass | 227.3 |
| Density | 1.18±0.1 g/cm3(Predicted) |
| Boling Point | 330.1±52.0 °C(Predicted) |
| pKa | 12.00±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
1-Piperidinecarboxylicacid, 4-(aminoiminomethyl)-, 1,1-dimethylethyl ester - Introduction
tert-Butyl (tert-Butyl) is an organic compound, usually in the form of white solid crystals.
Nature:
tert-Butyl has good stability and can be stored stably at room temperature. It has low solubility and is soluble in some organic solvents such as diethyl ether, dichloromethane and alcoholic solvents. It has moderate acidity.
Use:
tert-Butyl is an important intermediate compound in the field of biology and medicine. It is mainly used in organic synthesis reactions and can be used as a medium or reagent. One of its main uses is as a protective group for the synthesis of peptide compounds, protecting the amino groups in amino acids to prevent damage during the reaction. In addition, it can also be used to synthesize biologically active compounds, such as drugs and new materials.
Preparation Method:
The preparation of tert-Butyl is usually prepared by the reaction of benzoic acid BOC imine and 4-piperidinomethylamine. In the reaction, first of all, the benzoic acid BOC imine and 4-piperidine methylamine are reacted with ammonium sulfite or sulfite as catalyst in an appropriate solvent to obtain the tert-Butyl product. Finally, the pure product was obtained by appropriate purification process.
Safety Information:
tert-Butyl is irritating and may cause discomfort when in contact with skin and eyes. Appropriate personal protective measures, such as gloves and protective glasses, are required during handling and storage. In addition, it should be ensured that the operation is carried out under well-ventilated conditions to avoid discomfort caused by inhalation. If contact or ingestion occurs, rinse immediately with plenty of water and seek medical advice.
Nature:
tert-Butyl has good stability and can be stored stably at room temperature. It has low solubility and is soluble in some organic solvents such as diethyl ether, dichloromethane and alcoholic solvents. It has moderate acidity.
Use:
tert-Butyl is an important intermediate compound in the field of biology and medicine. It is mainly used in organic synthesis reactions and can be used as a medium or reagent. One of its main uses is as a protective group for the synthesis of peptide compounds, protecting the amino groups in amino acids to prevent damage during the reaction. In addition, it can also be used to synthesize biologically active compounds, such as drugs and new materials.
Preparation Method:
The preparation of tert-Butyl is usually prepared by the reaction of benzoic acid BOC imine and 4-piperidinomethylamine. In the reaction, first of all, the benzoic acid BOC imine and 4-piperidine methylamine are reacted with ammonium sulfite or sulfite as catalyst in an appropriate solvent to obtain the tert-Butyl product. Finally, the pure product was obtained by appropriate purification process.
Safety Information:
tert-Butyl is irritating and may cause discomfort when in contact with skin and eyes. Appropriate personal protective measures, such as gloves and protective glasses, are required during handling and storage. In addition, it should be ensured that the operation is carried out under well-ventilated conditions to avoid discomfort caused by inhalation. If contact or ingestion occurs, rinse immediately with plenty of water and seek medical advice.
Last Update：2024-04-09 20:52:54
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View History
1-Piperidinecarboxylicacid, 4-(aminoiminomethyl)-, 1,1-dimethylethyl ester
6-Methoxy-3-indolecarboxylic Acid
Pentasaccharide N-3 Intermediate
Pregn-4-ene-3,11,20-trione, 17-hydroxy-21-[(1-oxoundecyl)oxy]- (9CI)
1-[(Tert-butoxy)carbonyl]-2-methylazetidine-3-carboxylic acid
Racemic Tamsulosin Hydrochloride (50 mg)
1-Naphthalenamine, 2-methyl-5-phenyl-
2-(氨甲基)-1H苯并[d]咪唑-6-羧酸盐酸盐
1H-Pyrazole-4-carboxaldehyde, 1-methyl-3-nitro- (9CI)
Tubotaiwin
6-Methoxy-3-indolecarboxylic Acid
Pentasaccharide N-3 Intermediate
Pregn-4-ene-3,11,20-trione, 17-hydroxy-21-[(1-oxoundecyl)oxy]- (9CI)
1-[(Tert-butoxy)carbonyl]-2-methylazetidine-3-carboxylic acid
Racemic Tamsulosin Hydrochloride (50 mg)
1-Naphthalenamine, 2-methyl-5-phenyl-
2-(氨甲基)-1H苯并[d]咪唑-6-羧酸盐酸盐
1H-Pyrazole-4-carboxaldehyde, 1-methyl-3-nitro- (9CI)
Tubotaiwin