1-(4-chlorophenyl)propan-1-amine - Names and Identifiers
1-(4-chlorophenyl)propan-1-amine - Physico-chemical Properties
Molecular Formula | C9H12ClN
|
Molar Mass | 169.65 |
Density | 1.093±0.06 g/cm3(Predicted) |
Melting Point | 67-68 °C |
Boling Point | 118-120 °C(Press: 15 Torr) |
Flash Point | 117.062°C |
Vapor Presure | 0.031mmHg at 25°C |
pKa | 9.13±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.543 |
1-(4-chlorophenyl)propan-1-amine - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Hazard Class | IRRITANT |
1-(4-chlorophenyl)propan-1-amine - Introduction
1-(4-chlorophenyl)propan-1-amine is an organic compound with the chemical formula C9H12ClN and a molecular weight of 169.65g/mol.
The following is a description of its nature, use, method and safety information:
Nature:
-Appearance: white crystalline solid or colorless liquid;
-melting point: 36-38 ℃;
-Boiling point: 233-235 ℃;
-Density: 1.096 g/mL;
-Solubility: Soluble in water and some organic solvents.
Use:
- 1-(4-chlorophenyl)propan-1-amine is an important organic synthesis intermediate;
-It is commonly used in drug synthesis, especially for the synthesis of antidepressants and norepinephrine reuptake inhibitors.
Preparation Method:
1-(4-chlorophenyl)propan-1-amine can be prepared by the following steps:
-First, 4-chlorobenzoic acid is reacted with polyethylene glycol to prepare 1-(4-chlorophenyl)-2-hydroxyacetic acid;
-Then, 1-(4-chlorophenyl)-2-hydroxyacetic acid is reacted with iodomethane to prepare 1-(4-chlorophenyl)-2-methoxyacetic acid;
-Finally, 1-(4-chlorophenyl)-2-methoxyacetic acid is reacted with ethylamine and dehydrated to give 1-(4-chlorophenyl)propan-1-amine.
Safety Information:
- 1-(4-chlorophenyl)propan-1-amine needs to be operated under appropriate laboratory conditions and controlled by professionals;
-The compound may be irritating and dangerous, and may cause irritation to the eyes, skin and respiratory tract;
-When in use, the chemical should be handled in strict accordance with the safety guidelines, including wearing protective glasses, gloves and respiratory protection equipment;
-During storage and transportation, keep it in a dry, well-ventilated place, away from fire and oxidizing agents, and avoid contact with strong acids or alkalis.
Last Update:2024-04-09 21:01:54