1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)吡咯烷-3-甲酸(R)-甲酯
SCH772984
CAS: 942183-80-4
Molecular Formula: C33H33N9O2
1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)吡咯烷-3-甲酸(R)-甲酯 - Names and Identifiers
1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)吡咯烷-3-甲酸(R)-甲酯 - Physico-chemical Properties
| Molecular Formula | C33H33N9O2 |
| Molar Mass | 587.67 |
| Density | 1.353±0.06(20.0000℃) |
| Melting Point | >214°C (dec.) |
| Boling Point | 857.3±65.0 °C(Predicted) |
| Solubility | DMSO (Slightly) |
| Appearance | Solid |
| Color | Pale Yellow |
| pKa | 12.05±0.40(Predicted) |
| Storage Condition | Refrigerator |
| In vitro study | SCH772984 is a novel, selective, ATP-competitive ERK1/2 inhibitor. SCH772984 inhibited the phosphorylation of the ERK substrate p90 ribosomal S6 kinase (T359/S363 phosphorylation-RSK) in a dose-dependent manner. SCH772984 also inhibits phosphorylation of residues in the activation loop of ERK itself. SCH772984 inhibited approximately 88% and 49% of the BRAF-mutant or RAS-mutant tumor cell lines, respectively, with EC50 values <500 nM. |
| In vivo study | SCH772984 treated the xenograft model at a tolerated dose to induce tumor regression. Sch 772984 acts on a model of anti-BRAF or MEK inhibitors, effectively inhibiting MAPK signaling and cell proliferation. |
1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)吡咯烷-3-甲酸(R)-甲酯 - Risk and Safety
| HS Code | 29339900 |
1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)吡咯烷-3-甲酸(R)-甲酯 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.702 ml | 8.508 ml | 17.016 ml |
| 5 mM | 0.34 ml | 1.702 ml | 3.403 ml |
| 10 mM | 0.17 ml | 0.851 ml | 1.702 ml |
| 5 mM | 0.034 ml | 0.17 ml | 0.34 ml |
Last Update：2024-01-02 23:10:35
1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)吡咯烷-3-甲酸(R)-甲酯 - Reference Information
| biological activity | SCH772984 is a novel specific inhibitor of ERK1/2, the IC50 in the cell-free assay is 4 nM and 1 nM, respectively, and has powerful efficacy against cancer cells containing RAS or BRAF mutations. |
| Target | Value |
| ERK2 (Cell-free assay) | 1 nM |
| ERK1 (Cell-free assay) | 4 nM |
Last Update：2024-04-09 21:11:58
Supplier List
Featured ProductsSpot supply
Product Name: SCH772984 Visit Supplier Webpage Request for quotationCAS: 942183-80-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SCH772984 Visit Supplier Webpage Request for quotationCAS: 942183-80-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SCH772984 Visit Supplier Webpage Request for quotationCAS: 942183-80-4
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: SCH772984 Visit Supplier Webpage Request for quotationCAS: 942183-80-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SCH772984 Visit Supplier Webpage Request for quotationCAS: 942183-80-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: SCH772984 Visit Supplier Webpage Request for quotationCAS: 942183-80-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SCH772984 Visit Supplier Webpage Request for quotationCAS: 942183-80-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SCH772984 Visit Supplier Webpage Request for quotationCAS: 942183-80-4
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: SCH772984 Visit Supplier Webpage Request for quotationCAS: 942183-80-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SCH772984 Visit Supplier Webpage Request for quotationCAS: 942183-80-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)吡咯烷-3-甲酸(R)-甲酯
2,5-二溴-3,4-二硝基噻吩
3-乙基-5-(2-羟基乙基)-4-甲基噻唑鎓 溴化物
羟基-四聚乙二醇-四氢吡喃醚
环丙烷羧酸,2-氟-,(1R-反式)-(9CI)
2-[(2-氰基乙酰基)氨基]-5,6-二氢-4H-环戊烷并[D]噻吩-3-甲酸乙酯
ETHYL 2-[[2-[(2-AMINOACETYL)AMINO]ACETYL]AMINO]ACETATE,HYDROCHLORIDE
4-[(三甲基硅基)乙炔基]吡啶-2-胺
Glycoursodeoxycholic Acid-3-O-β-glucuronide Disodium Salt
2-氟-4-羟基苯乙酸甲酯
2,5-二溴-3,4-二硝基噻吩
3-乙基-5-(2-羟基乙基)-4-甲基噻唑鎓 溴化物
羟基-四聚乙二醇-四氢吡喃醚
环丙烷羧酸,2-氟-,(1R-反式)-(9CI)
2-[(2-氰基乙酰基)氨基]-5,6-二氢-4H-环戊烷并[D]噻吩-3-甲酸乙酯
ETHYL 2-[[2-[(2-AMINOACETYL)AMINO]ACETYL]AMINO]ACETATE,HYDROCHLORIDE
4-[(三甲基硅基)乙炔基]吡啶-2-胺
Glycoursodeoxycholic Acid-3-O-β-glucuronide Disodium Salt
2-氟-4-羟基苯乙酸甲酯