1-苄基-4-哌啶甲醇
1-Benzyl-4-Piperdinemethanol
CAS: 67686-01-5
Molecular Formula: C13H19NO
1-苄基-4-哌啶甲醇 - Names and Identifiers
1-苄基-4-哌啶甲醇 - Physico-chemical Properties
| Molecular Formula | C13H19NO |
| Molar Mass | 205.3 |
| Density | 1.056±0.06 g/cm3(Predicted) |
| Boling Point | 135-138°C (0.2 mmHg) |
| Flash Point | 139.8°C |
| Vapor Presure | 0.00023mmHg at 25°C |
| pKa | 14.94±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.551 |
| Physical and Chemical Properties | Boiling Point: 135 - 138 |
1-苄基-4-哌啶甲醇 - Risk and Safety
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| Hazard Class | IRRITANT |
1-苄基-4-哌啶甲醇 - Reference Information
| Introduction | 1-benzyl-4-piperidinemethanol as donepezil hydrochloride is an important intermediate of acetylcholinesterase inhibitors, is a long-acting Alzheimer's disease (AD, also known as Alzheimer's disease or senile dementia) treatment drugs, developed by the Japan Medical Science Corporation, it was first approved in the United States in 1997 and is currently available in more than 70 countries worldwide. |
| product features | 1-benzyl-4-piperidine methanol is characterized by low dose, less toxic side effects and good tolerance, it plays an important role in the treatment of Alzheimer's disease. |
| synthetic method | a route of 1-benzyl-4-piperidine methanol, a key intermediate of donepezil hydrochloride, is reported in the literature (J.Heterocycl.Chem.,1978,15,675-676) from 1-benzyl-4-piperidone, trimethyliodide oxide (Me3S(O)I) is reacted Corey-Chaykovsky with 1-benzyl-4-piperidone in the presence of sodium hydride to obtain epoxide, the target product was obtained by ring-opening with lithium aluminum tetrahydrate in two-step yield of 42.3%. |
Last Update：2024-04-09 20:52:54
Supplier List
Spot supply
Product Name: N-benzyl-4-piperidinemethanol Visit Supplier Webpage Request for quotationCAS: 67686-01-5
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: (1-BENZYLPIPERIDIN-4-YL)METHANOL Visit Supplier Webpage Request for quotationCAS: 67686-01-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: (1-BENZYLPIPERIDIN-4-YL)METHANOL Visit Supplier Webpage Request for quotationCAS: 67686-01-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: N-benzyl-4-piperidinemethanol Visit Supplier Webpage Request for quotationCAS: 67686-01-5
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: (1-BENZYLPIPERIDIN-4-YL)METHANOL Visit Supplier Webpage Request for quotationCAS: 67686-01-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: (1-BENZYLPIPERIDIN-4-YL)METHANOL Visit Supplier Webpage Request for quotationCAS: 67686-01-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
1-苄基-4-哌啶甲醇
(氯甲基)甲基-二氯硅烷
1,3-双(2,6-二(1-丁基-戊基基)苯基)-1H-咪唑-3-鎓氯化物
L-精氨酸-L-焦谷氨酸 精氨酸 PCA 精氨酸焦谷氨酸 L-精氨酸 焦谷氨酸盐 精氨酸 PCA盐
7-苄基-5-溴-4-氯-7H-吡咯并[2,3-d]嘧啶
5-氯-2-三氟甲基吡啶
(S)-2-BOC-氨基-3-(4-羟基-2,6-二甲基苯基)丙酸
4-氨基-1-金刚烷甲酸甲酯(消旋)
2-甲基-4-氧代环戊-2-烯-1-甲酸乙酯
2-羟基-5-碘-3-甲氧基苯甲醛
(氯甲基)甲基-二氯硅烷
1,3-双(2,6-二(1-丁基-戊基基)苯基)-1H-咪唑-3-鎓氯化物
L-精氨酸-L-焦谷氨酸 精氨酸 PCA 精氨酸焦谷氨酸 L-精氨酸 焦谷氨酸盐 精氨酸 PCA盐
7-苄基-5-溴-4-氯-7H-吡咯并[2,3-d]嘧啶
5-氯-2-三氟甲基吡啶
(S)-2-BOC-氨基-3-(4-羟基-2,6-二甲基苯基)丙酸
4-氨基-1-金刚烷甲酸甲酯(消旋)
2-甲基-4-氧代环戊-2-烯-1-甲酸乙酯
2-羟基-5-碘-3-甲氧基苯甲醛