Molecular Formula | C15H19F3O12S |
Molar Mass | 480.36 |
Density | 1.50±0.1 g/cm3(Predicted) |
Melting Point | 118-122°C |
Boling Point | 481.6±45.0 °C(Predicted) |
Specific Rotation(α) | [α]D20 -14~-17゜(c=1,CHCl3) |
Flash Point | 245.061°C |
Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
Vapor Presure | 0mmHg at 25°C |
Appearance | neat |
Color | White to Off-White |
BRN | 4341413 |
Storage Condition | -20°C |
Refractive Index | -16 ° (C=1, CHCl3) |
MDL | MFCD00012353 |
Physical and Chemical Properties | Colourless or nearly colourless crystals, mp119 - 122 ; soluble in acetonitrile, DMSO, methanol, acetone, insoluble in aqueous media |
Use | Sugar compounds, used to synthesize various derivatives of sugars modified in C- 2, such as 2-halo-glucose; Preparation of thioethers. |
Hazard Symbols | Xi - Irritant |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 10-21 |
HS Code | 29329990 |
Use | mannose trifluorosulfonate is a type of salt used in the preparation of 2-deoxy-2-18f-β-d-glucopyranose (18FDG). The synthesis of carbohydrate precursors. 18FDG is the most widely used radiotracer in positron emission tomography to study cellular metabolism. FDG is naturally taken up by cells like glucose, but cannot participate in metabolic reactions. Due to the characteristically high metabolic rate of cancer cells, the 18FDG radiotracer accumulates in the cancer cells. 18F emits low energy positron, which can be detected by PET scanner. The synthesis of 18FDG requires the production of 18F from 18O-rich water using a cyclotron, which is typically performed using an 18FDG synthesizer. Limiting factors for the use of 18FDG are the relatively short half-life of 18F (about 100 minutes) and the low yield of 18FDG synthesis. The entire process from the preparation of 18F, the synthesis of 18FDG, and its injection into the patient must be completed within a few hours. This led to the birth of several automated 18FDG synthesizers, which assisted this process with a set of equipment. |