1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide
YS-49
CAS: 132836-42-1
Molecular Formula: C20H20BrNO2
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide - Names and Identifiers
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide - Physico-chemical Properties
| Molecular Formula | C20H20BrNO2 |
| Molar Mass | 386.2823 |
| Solubility | H2O: >10mg/mL |
| Appearance | solid |
| Storage Condition | 2-8°C |
| In vitro study | YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively. YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level. Cell Viability Assay Cell Line: RAVSMC and RAW 264.7 cells Concentration: 10 μΜ, 30 μΜ and 100 μΜ (RAVSMC cells); 1 μΜ, 10 μΜ and 100 μM (RAW 264.7 cells) Incubation Time: 18 hours Result: Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively. Western Blot Analysis Cell Line: RAVSMC and RAW 264.7 cells Concentration: 10 μΜ, 30 μΜ and 100 μΜ Incubation Time: 18 hours Result: Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. |
| In vivo study | YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. Animal Model: Male Sprague Dawley rats (250-300 g) Dosage: 5 mg/kg Administration: Intraperitoneal injection; 8 hours Result: Serum NOx levels were significantly reduced. |
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R50 - Very Toxic to aquatic organisms |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.473 ml | 12.367 ml | 24.734 ml |
| 5 mM | 0.495 ml | 2.473 ml | 4.947 ml |
| 10 mM | 0.247 ml | 1.237 ml | 2.473 ml |
| 5 mM | 0.049 ml | 0.247 ml | 0.495 ml |
Last Update：2024-01-02 23:10:35
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide - Reference Information
| biological activity | YS-49 is an activator of PI3K/Akt (downstream target of RhoA), which can reduce the activation of RhoA/PTEN in 3-methylcholine treated cells. YS-49 can inhibit angiotensin II (Ang II) by inducing heme oxygenase (HO-1) to stimulate the proliferation of VSMC cells. YS-49 is an isoquinoline compound alkaloid, which has a strong positive inotropic effect because it can activate cardiac β-adenoceptors. |
| in vitro study | YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μ m and 30 μ m, respectively. YS-49 (10-100 μ m; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level. Cell Viability Assay Cell Line: RAVSMC and RAW 264.7 cells Concentration: 10 μ, 30 μM and 100 μM (RAVSMC cells); 1 μM, 10 μM and 100 μM (RAW 264.7 cells) Incubation Time: 18 hours Result: Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS INF-γ, with IC 50 values of 22 and 30 μM, respectively. Western Blot Analysis Cell Line: RAVSMC and RAW 264.7 cells Concentration: 10 μ, 30 μ and 100 μ Incubation Time: 18 hours Result: Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. |
| Cell Line: | RAVSMC and RAW 264.7 cells RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μΜ, 30 μΜ and 100 μΜ (RAVSMC cells); 1 μΜ, 10 μΜ and 100 μM (RAW 264.7 cells) 10 μΜ, 30 μΜ and 100 μΜ |
| Incubation Time: | 18 hours 18 hours |
| Result: | Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS INF-γ, with IC 50 values of 22 and 30 μM, respectively. Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. Serum NOx levels were significantly reduced. |
| in vivo study | YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley Rats) treatment significantly reduces serum NOx levels in LPS-treated Rats, the NOx levels reduce from 86 μ m to 34 μ m. Animal Model: Male Sprague Dawley Rats (250-300 g) Dosage: 5 mg/kg Administration: Intraperitoneal injection; 8 hours result: serum NOx levels were significantly reduced. |
| Animal Model: | Male Sprague Dawley rats (250-300 g) |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; 8 hours |
Last Update：2024-04-10 22:29:15
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Product Name: YS-49 Visit Supplier Webpage Request for quotationCAS: 132836-42-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: YS-49 Visit Supplier Webpage Request for quotationCAS: 132836-42-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: YS-49 Visit Supplier Webpage Request for quotationCAS: 132836-42-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: YS-49 Visit Supplier Webpage Request for quotationCAS: 132836-42-1
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Email: 3008007409@qq.com
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View History
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide
1-Naphthalenepropanol, α-ethenyl-1,2,3,4,4a,7,8,8a-octahydro-7-hydroxy-α,1,2,4a,5-pentamethyl- (9CI)
L-Calciumtartrate
5-Bromo-3-fluorophenylene-1,2-diamine, 5-Bromo-2,3-diamino-1-fluorobenzene
epoxy resin insulation powder coating
N-(3-acetyl-2-methyl-1-benzofuran-5-yl)-4-isopropylbenzenesulfonamide
N-BUTYRALDEHYDE-PFBOA DERIVATIVE
N-[4-(Trifluoromethyl)phenyl]-5-benzylisoxazole-4-carboxamide
861909-53-7
318247-56-2
1-Naphthalenepropanol, α-ethenyl-1,2,3,4,4a,7,8,8a-octahydro-7-hydroxy-α,1,2,4a,5-pentamethyl- (9CI)
L-Calciumtartrate
5-Bromo-3-fluorophenylene-1,2-diamine, 5-Bromo-2,3-diamino-1-fluorobenzene
epoxy resin insulation powder coating
N-(3-acetyl-2-methyl-1-benzofuran-5-yl)-4-isopropylbenzenesulfonamide
N-BUTYRALDEHYDE-PFBOA DERIVATIVE
N-[4-(Trifluoromethyl)phenyl]-5-benzylisoxazole-4-carboxamide
861909-53-7
318247-56-2