1(2H)-Quinoxalineacetic acid, 3,4-dihydro-7-(1H-imidazol-1-yl)-6-nitro-2,3-dihydro-
ZONAMPANEL
CAS: 210245-80-0
Molecular Formula: C13H9N5O6
1(2H)-Quinoxalineacetic acid, 3,4-dihydro-7-(1H-imidazol-1-yl)-6-nitro-2,3-dihydro- - Names and Identifiers
1(2H)-Quinoxalineacetic acid, 3,4-dihydro-7-(1H-imidazol-1-yl)-6-nitro-2,3-dihydro- - Physico-chemical Properties
| Molecular Formula | C13H9N5O6 |
| Molar Mass | 331.24 |
| Density | 1.82±0.1 g/cm3(Predicted) |
| pKa | 3.20±0.10(Predicted) |
| In vitro study | Zonampanel inhibits the human MRP4-mediated transport of [ 3 H]oestradiol 17-D-glucuronide in a concentration-dependent manner. In contrast, Zonampanel (up to 1000 mM) does not inhibit the human MRP2- or BCRP-mediated transport of [ 3 H]oestradiol 17-D-glucuronide or [ 3 H]methotrexate. Zonampanel inhibits the uptake of typical substrates by Oat1, Oat2, and Oat3 with inhibition constant (K i ) values of 7.02 to 10.4 μM. A time- and saturable concentration-dependent increase in [ 14 C]Zonampanel uptake is observed in these cells [K m values: 13.4 to 53.6 μM]. |
| In vivo study | In in vivo experiments, probenecid and cimetidine decrease intrinsic clearance for both the renal secretion and biliary excretion of Zonampanel. |
1(2H)-Quinoxalineacetic acid, 3,4-dihydro-7-(1H-imidazol-1-yl)-6-nitro-2,3-dihydro- - References
| biological activity | Zonampanel (YM 872) is a selective AMPA receptor antagonist. |
Last Update：2024-04-09 21:04:16
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View History
1(2H)-Quinoxalineacetic acid, 3,4-dihydro-7-(1H-imidazol-1-yl)-6-nitro-2,3-dihydro-
2-(4-Methoxyphenyl)-5-methylthiazole-4-carboxylic acid ethyl ester
o-Chloro-p-nitrophenyl-β-D-xylopyranoside
1-(3,4-difluorophenyl)pentane-1,3-dione
2-Hydroxybutyric acid
[(5,6-Dihydro-4-phenyl-6-oxopyrimidin-2-yl)thio]acetic acid sodium salt
2-butoxy-N-(1,3-thiazol-2-yl)benzamide
1-(6-CHLORO-3-PYRIDINYL)-1-ETHANONE
tert-butyl (3R,5R)-3-amino-5-hydroxypiperidine-1-carboxylate
(-)-id
2-(4-Methoxyphenyl)-5-methylthiazole-4-carboxylic acid ethyl ester
o-Chloro-p-nitrophenyl-β-D-xylopyranoside
1-(3,4-difluorophenyl)pentane-1,3-dione
2-Hydroxybutyric acid
[(5,6-Dihydro-4-phenyl-6-oxopyrimidin-2-yl)thio]acetic acid sodium salt
2-butoxy-N-(1,3-thiazol-2-yl)benzamide
1-(6-CHLORO-3-PYRIDINYL)-1-ETHANONE
tert-butyl (3R,5R)-3-amino-5-hydroxypiperidine-1-carboxylate
(-)-id