Name | 1,4-Benzodioxan-6-amine |
Synonyms | AKOS AUF02030 AKOS BBS-00000780 LABOTEST-BB LT00012696 1,4-Benzodioxan-6-amine 3,4-ETHYLENDIOXYANILINE 6-AMINO-1,4-BENZODIOXAN 6-Amino-1,4-benzodioxan 6-Amino-1,4-benzodioxane 3,4-ETHYLENEDIOXYANILINE 6-AMINO-1,4-BENZODIOXANE 1,4-benzodioxan-6-ylamine 2,3-DIHYDRO-1,4-BENZODIOXIN-6-AMINE 2,3-Dihydro-1,4-benzodioxin-6-amine |
CAS | 22013-33-8 |
EINECS | 244-718-4 |
InChI | InChI=1/C8H9NO2/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-2,5H,3-4,9H2 |
Molecular Formula | C8H9NO2 |
Molar Mass | 151.16 |
Density | 1.231 g/mL (lit.) |
Melting Point | 29-31 °C (lit.) |
Boling Point | 116-118°C 3mm |
Flash Point | >230°F |
Water Solubility | insoluble |
Vapor Presure | 0.0017mmHg at 25°C |
Appearance | Viscous Liquid After Melting |
Specific Gravity | 1.231 |
Color | Brown to black |
BRN | 6447 |
pKa | 4.83±0.20(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
Sensitive | Light Sensitive |
Refractive Index | n20/D 1.599(lit.) |
MDL | MFCD00006824 |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R38 - Irritating to the skin |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. |
UN IDs | 2810 |
WGK Germany | 3 |
HS Code | 29329995 |
Hazard Note | Harmful |
Hazard Class | 6.1 |
Packing Group | III |
introduction | 6-amino -1, 4-benzodioxane is one of the benzodioxane compounds. At present, there are few studies on its synthesis and application. In this case, the synthesis of this compound may provide support for the synthesis of some new drugs in the future. 6-Amino-1, 4-benzodioxane is a probe fragment that determines its ability to induce the conformation of HIV-1 transactivated response element (TAR)RNA through screening in an effort to develop TAR-bound antiviral drugs. |
Properties | 6-amino-1, 4-benzodioxane is a brown to black viscous liquid. |
Preparation | Catechol is used as the starting material, potassium carbonate is used as the acid binding agent, and 1,2-dibromoethane is substituted in a polar solvent to generate 1,4-benzodioxane, 1,4-benzodioxane is nitrated with nitric acid in concentrated sulfuric acid to generate 6-nitro-1, 4-benzodioxane, 6-Nitro-1, 4-benzodioxane is hydrogenated and reduced in a protic solvent under the action of zinc powder and acetic acid to obtain 6-amino-1, 4-benzodioxane. Its synthetic route is as follows. |