(R)-N-Boc-2-hydroxymethylpiperidine is an organic compound with the chemical formula (R)-[(tert-butoxycarbonyl)amino]methylpyridin-2-ol. It is a white to pale yellow solid.
Nature:
- (R)-N-Boc-2-hydroxymethylpiperidine is soluble in organic solvents such as ethanol and methylene chloride.
-It is a weak base, stable under neutral or acidic conditions.
-It can participate in nucleophilic reactions and metal-catalyzed reactions.
Use:
- (R)-N-Boc-2-hydroxymethylpiperidine is an important synthetic intermediate that can be used to synthesize a variety of organic compounds, such as drugs and pesticides.
-It can be used as a catalyst to participate in asymmetric synthesis reactions and produce compounds with optical activity.
Preparation Method:
(R)-N-Boc-2-hydroxymethylpiperidine can be synthesized by a two-step reaction.
In the first step, piperidine is reacted with methyl sodium bromide to obtain 2-hydroxymethylpiperidine.
In the second step, 2-hydroxymethylpiperidine is reacted with (Boc)2O to obtain (R)-N-Boc-2-hydroxymethylpiperidine.
Safety Information:
- (R)-N-Boc-2-Hydroxymethylpiperidine has limited safety information, so it is necessary to follow relevant laboratory safety procedures when using and handling.
-It may be harmful to the environment and should not be directly discharged into the natural environment.
-When storing, it should be stored in a dry, sealed container, away from heat and fire sources.