(4E,12E)-6-(β-D-Glucopyranosyloxy)-4,12-tetradecadiene-8,10-diyne-1,7-diol
Lobetyolin
CAS: 136085-37-5
Molecular Formula: C20H28O8
(4E,12E)-6-(β-D-Glucopyranosyloxy)-4,12-tetradecadiene-8,10-diyne-1,7-diol - Names and Identifiers
| Name | Lobetyolin |
| Synonyms | Lobetyolin Iobetyolin Lebetyolin hydroxy-1-penten-1-yl]-7-nonene-3,5-diyn-1-yl β-D-Glucopyranoside, (7E)-2-hydroxy-1-[(1E)-5- (4E,12E)-6-β-D-Glucopyranosyloxytetradeca-4,12-diene-8,10-diyne-1,7-diol (4E,12E)-6-(β-D-Glucopyranosyloxy)-4,12-tetradecadiene-8,10-diyne-1,7-diol |
| CAS | 136085-37-5 |
| InChI | InChI=1/C20H28O8/c1-2-3-4-5-7-10-14(23)15(11-8-6-9-12-21)27-20-19(26)18(25)17(24)16(13-22)28-20/h2-3,8,11,14-26H,6,9,12-13H2,1H3/b3-2+,11-8+/t14?,15?,16-,17-,18+,19-,20-/m1/s1 |
(4E,12E)-6-(β-D-Glucopyranosyloxy)-4,12-tetradecadiene-8,10-diyne-1,7-diol - Physico-chemical Properties
| Molecular Formula | C20H28O8 |
| Molar Mass | 396.433 |
| Melting Point | >74°C (dec.) |
| Boling Point | 698.5±55.0 °C at 760 mmHg |
| Specific Rotation(α) | (c, 0.12 in Me2CO)，-8.9 |
| Solubility | Soluble in water or DMSO: mother liquor preservation: sub-package and freeze storage to avoid repeated freezing and thawing;-20 ℃,1 month;-80 ℃,6 months |
| Appearance | Pale yellow crystal |
| Color | Yellow to Dark Orange |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.607 |
| MDL | MFCD09953797 |
| Physical and Chemical Properties | Codonopsis pilosula from Campanulaceae |
(4E,12E)-6-(β-D-Glucopyranosyloxy)-4,12-tetradecadiene-8,10-diyne-1,7-diol - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
(4E,12E)-6-(β-D-Glucopyranosyloxy)-4,12-tetradecadiene-8,10-diyne-1,7-diol - Reference
| Reference Show more | 1. Chen Tianchao, Geng Mengli, Chang Qianqian, et al. Study on the Correlation of Physical Parameters and Chemical Components of Different Pills of Codonopsis pilosula before and after Dissolution [J]. ISTIC CSCD CA 2020 2. Chen Jiangpeng, Dai Jundong, Pei Wenxuan, etc. Study on Standardization of Processing Technology of Rice Fried Codonopsis pilosula Based on Correlation Analysis of Functional Components and Shape Indexes [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 043(012):2543-2551. 3. Chen Tianchao, Wang Jiao, Li Ruiying, et al. Study on Changes of Properties and Active Components of Codonopsis pilosula Based on Stir-frying [J]. Modern Chinese Traditional Chinese Medicine, 2019, 21(02):96-101. 4. Zhao Na, Fu Yao, Zhang Shihang, Zhang Dong, Zhang Dafang. HPLC-PDA-ELSD Determination of 10 Components in Shenqi Wuweizi Capsule and Chemical Pattern Recognition [J]. China Modern Applied Pharmacy, 2021,38(05):609-614. 5. Fan Xiaolong, Chen Ran, Wu Wanqin, Liu Guojiao, Huang Kun, Jiang Feng. Determination of 20 Functional Components of Icariin in Food by Liquid Chromatography Tandem Mass Spectrometry [J]. Food and machinery, 2021,37(01):86-93 98. 6. Shen, Lijuan, et al. "Identification of bioactive ingredients with immuno-enhancement and anti-oxidative effects from Fufang-Ejiao-Syrup by LC-MSn combined with bioassays." Journal of pharmaceutical and biomedical analysis 117 (2016): 363-371.https://doi.o 7. Xia, Yuanyuan, et al. "Characterization, quantitation and similarity evaluation of Codonopsis lanceolata from different regions in China by HPLC-Q-TQF-MS and chemometrics." Journal of Food Composition and Analysis 62 (2017): 134-142.https://doi.org/10.1016 8. [IF = 4.556] Yuanyuan Xia et al. "Characterization, quantitation and similarity evaluation of Codonopsis lanceolata from different regions in China by HPLC-Q-TQF-MS and chemometrics." J Food Compos Anal. 2017 Sep;62:134 9. [IF = 3.935] Lijuan Shen et al. "Identification of bioactive ingredients with immuno-enhancement and anti-oxidative effects from Fufang-Ejiao-Syrup by LC-MSn combined with bioassays." J Pharmaceut Biomed. 2016 Jan;117:363 10. [IF = 3.373] Binjun Yan et al. "Root Cause Analysis of Quality Defects Using HPLC-MS Fingerprint Knowledgebase for Batch-to-batch Quality Control of Herbal Drugs." Phytochem Analysis. 2015 Jul;26(4):261-268 11. [IF = 4.821] Xiangwei Chang et al. "Untargeted metabolomics approach reveals the issue-specific markers of balloon flower root (Platycodi Radix) using UPLC-Q-TOF/MS." Microchem J. 2021 Sep;168:106447 |
(4E,12E)-6-(β-D-Glucopyranosyloxy)-4,12-tetradecadiene-8,10-diyne-1,7-diol - Introduction
Lobetyolin is a compound with the chemical formula C15H20O10, which belongs to the triterpenoid compound in natural products. It is mainly found in plants such as Codonopsis pilosula (scientific name: Codonopsis pilosula).
Lobetyolin has a variety of biological activities, such as enhancing immunity, anti-inflammatory, antioxidant and anti-tumor effects. It can regulate the human immune system, improve the immune function of the body, and help to resist diseases. In addition, Lobetyolin also has anti-aging and anti-hypoxia properties.
The preparation of Lobetyolin can be obtained by extracting the rhizome and other parts of Codonopsis pilosula. A commonly used extraction method is to use a mixed solvent of alcohol and water to stir and extract, and then further purify and crystallize the extract, and finally obtain Lobetyolin with high purity.
Some safety factors need to be paid attention to when using Lobetyolin. Although Lobetyolin comes from natural plants, some people may be allergic to it. Allergy testing should be done before use and used under the guidance of a physician. In addition, for pregnant women, lactating women and children, as well as individuals with special diseases, the advice of a doctor should be consulted before use.
In General, Lobetyolin has good medicinal potential and has been widely used in the field of Chinese medicine. However, it is necessary to pay attention to rational use of drugs and follow the guidance of doctors.
Lobetyolin has a variety of biological activities, such as enhancing immunity, anti-inflammatory, antioxidant and anti-tumor effects. It can regulate the human immune system, improve the immune function of the body, and help to resist diseases. In addition, Lobetyolin also has anti-aging and anti-hypoxia properties.
The preparation of Lobetyolin can be obtained by extracting the rhizome and other parts of Codonopsis pilosula. A commonly used extraction method is to use a mixed solvent of alcohol and water to stir and extract, and then further purify and crystallize the extract, and finally obtain Lobetyolin with high purity.
Some safety factors need to be paid attention to when using Lobetyolin. Although Lobetyolin comes from natural plants, some people may be allergic to it. Allergy testing should be done before use and used under the guidance of a physician. In addition, for pregnant women, lactating women and children, as well as individuals with special diseases, the advice of a doctor should be consulted before use.
In General, Lobetyolin has good medicinal potential and has been widely used in the field of Chinese medicine. However, it is necessary to pay attention to rational use of drugs and follow the guidance of doctors.
Last Update：2024-04-09 20:52:54
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View History
(4E,12E)-6-(β-D-Glucopyranosyloxy)-4,12-tetradecadiene-8,10-diyne-1,7-diol
4-(dimethylamino)phenyl-diphenyl-phosphine
1516-32-1
5-Methyl-1,2,3,4-tetrahydroquinoxaline
1-(2,4-dichlorophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea
4-(2-phenylethyl)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol
3-[(E)-2-Decenyl]-3,4-dihydro-2,5-furandione
1144-74-7
1805469-84-4
50-39-5
4-(dimethylamino)phenyl-diphenyl-phosphine
1516-32-1
5-Methyl-1,2,3,4-tetrahydroquinoxaline
1-(2,4-dichlorophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea
4-(2-phenylethyl)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol
3-[(E)-2-Decenyl]-3,4-dihydro-2,5-furandione
1144-74-7
1805469-84-4
50-39-5