(3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST 2238)
(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol
CAS: 156722-18-8
Molecular Formula: C23H34O4
(3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST 2238) - Names and Identifiers
(3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST 2238) - Physico-chemical Properties
| Molecular Formula | C23H34O4 |
| Molar Mass | 374.51 |
| Density | 1.226±0.06 g/cm3(Predicted) |
| Boling Point | 451.3±45.0 °C(Predicted) |
| pKa | 14.02±0.70(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | Rostafuroxin (PST 2238) competitively inhibits Ouabain (HY-B0542) binding and signaling. Rostafuroxin antagonizes the molecularand functional effects of Ouabain by reversing the ouabain-induced, Src-dependent Na + ,K + -ATPase phosphorylation and activation. Rostafuroxin (0.125-128 μM; for 24 h post treatment) has less than 20% reduction in cell viability in A549 cells and HSAEC. Rostafuroxin inhibits the expression of RSV-GFP in HSAEC (IC 50 =1.8 μM) and A549 cells (IC 50 =14.8 μM). Rostafuroxin displaced [ 3 H]Ouabain from the dog kidney Na + ,K + -ATPase receptor (IC50=1.5 nM), is devoid of cardiac inotropic activity in isolated guinea pig atria, and shows no affinity up to 10 -4 M with general (R1, R2, a1, a2, A1, A2, M1, M2, H1, H2, 5-HT1, 5-HT2, Ca2+ channels, TXA2/PGH2, PAF, GABAA, GABAB, DA-NE-5-HT uptake, glutammate,glycine, benzodiazepine) and hormonal (estrogenic, progestinic, androgenic, mineralcorticoid) receptors. |
| In vivo study | Rostafuroxin (PST 2238; 1 mg/kg/day; gavage; for 3 weeks) decreases SBP and improves acetylcholine-induced relaxation. Animal Model: Male 7-week-old Wistar rats Dosage: 1 mg/kg Administration: Gavage; daily; for 3 weeks Result: Decreased SBP, improved acetylcholine-induced relaxation via enhanced nitric oxide synthesis and bioavailability, decreased superoxide anion generation from NAD(P)H oxidase and cyclooxygenase-2 and reduced cytoplasmic tyrosine kinase Src phosphorylation. |
(3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST 2238) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.67 ml | 13.351 ml | 26.702 ml |
| 5 mM | 0.534 ml | 2.67 ml | 5.34 ml |
| 10 mM | 0.267 ml | 1.335 ml | 2.67 ml |
| 5 mM | 0.053 ml | 0.267 ml | 0.534 ml |
Last Update：2024-01-02 23:10:35
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View History
(3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST 2238)
1-(9H-Fluoren-9-ylmethyl) 4-methyl piperidine-1,4-dicarboxylate
1-cetylpyridinium chloride monohydrate
2-(diethylamino)-2-[3-(trifluoromethyl)phenyl]acetic acid hydrochloride
70161-20-5
1393330-40-9
3-(4-chlorophenyl)-N-[3-cyano-1-(2-methoxyethyl)-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidin-2-ylidene]acrylamide
1-(9H-Fluoren-9-ylmethyl) 4-methyl piperidine-1,4-dicarboxylate
1-cetylpyridinium chloride monohydrate
2-(diethylamino)-2-[3-(trifluoromethyl)phenyl]acetic acid hydrochloride
70161-20-5
1393330-40-9
3-(4-chlorophenyl)-N-[3-cyano-1-(2-methoxyethyl)-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidin-2-ylidene]acrylamide