(2-MERCAPTOETHYL)TRIMETHYLAMMONIMUM IODIDE ACETATE

(2-MERCAPTOETHYL)TRIMETHYLAMMONIMUM IODIDE ACETATE - Names and Identifiers

Name	S-Acetylthiocholine iodide
Synonyms	Acetylthiocholinjodid Acetylthiocholine iodide acetylthiocholinediiodide s-acetylthio-choliniodide S-Acetylthiocholine iodide 2-acetylthioethyltrimethylammonium iodide (2-Mercaptoethyl)trimethylammonium iodide acetate (2-MERCAPTOETHYL)TRIMETHYLAMMONIMUM IODIDE ACETATE Ethanaminium,2-(acetylthio)-N,N,N-trimethyl-,iodide 2-(Acetylsulfanyl)-N,N,N-trimethylethanaminium iodide S-[2-(trimethyl-lambda5-azanyl)ethyl] ethanethioate hydroiodide S-ACETYLTHIOCHOLINE IODIDE extrapure AR substrate for acetylcholinesterase
CAS	1866-15-5
EINECS	217-474-1
InChI	InChI=1/C7H16NOS.HI/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChIKey	NTBLZMAMTZXLBP-UHFFFAOYSA-M

(2-MERCAPTOETHYL)TRIMETHYLAMMONIMUM IODIDE ACETATE - Physico-chemical Properties

Molecular Formula	C7H16INOS
Molar Mass	289.18
Density	1.4885 (estimate)
Melting Point	205-210°C(lit.)
Solubility	Soluble in water
Appearance	White powder
Color	white
BRN	3916578
Storage Condition	2-8°C
Sensitive	Light Sensitive & Hygroscopic
MDL	MFCD00011819
Use	A substrate for acetylcholinesterase, a nicotinic acetylcholine receptor agonist. It is often used to determine the activity of acetylcholinesterase by chromaticity method.

(2-MERCAPTOETHYL)TRIMETHYLAMMONIMUM IODIDE ACETATE - Risk and Safety

Risk Codes	R21 - Harmful in contact with skin R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	FZ9865000
FLUKA BRAND F CODES	3-8-10
TSCA	Yes
HS Code	29309099
Hazard Class	6.1
Packing Group	III

(2-MERCAPTOETHYL)TRIMETHYLAMMONIMUM IODIDE ACETATE - Reference

Reference

1. Shen Yifan, Shen Huimin, Yue Xiuli, et al. Breeding of Avermectin Resistant Strain of Tetranychus diphylla and Changes of Its Detoxification Enzyme Activity [J]. Plant Protection 2014(5):44-48.
2. Luo Qin, Zu Yunhong, Shi Kaiqiong, et al. Study on Removal of Pesticide Residues in Vegetables by Slightly Acidic Electrolyzed Water [J]. Journal of Food Safety and Quality Testing, 2014(11):3657-3663.
3. Wang Huannan, Yang Hua, Gu Yinglin, et al. Isolation, Identification and Bioactivity of Secondary Metabolites of Oyster Symbiotic Bacteria [J]. Journal of Liaocheng University (Natural Science Edition), 2019(5).
4. Ling Qingzhi, Dong Lihui, Fan Sanwei, isolation of Endophytic Fungi Inhibiting Acetylcholinesterase Active Substances in Huperzia serrata [J]. Anhui Agricultural Sciences, 2012(30):14706-14707.
5. [IF = 7.46] Yue Zhang et al."A dual-signal sensing platform based on nanosheet materials for ratiometric fluorescence and colorimetric detection of enzyme activities in human blood." Sensor Actuat B- Chem. 2021 Nov;346:130531
6. [IF = 7.217] Qiuyuan Fang et al."Histamine-4 receptor antagonist ameliorates Parkinson-like pathology in the striatum." Brain Behav Immun.2021 Feb;92:127
7. [IF = 4.952] Jingyang Yao et al."Free, soluble-bound and insoluble-bound phenolics and their bioactivity in raspberry pomace." Lwt Food Sci Technol. 2021 Jan;135:109995
8. [IF = 4.24] Nana Li et al."Characterization of phenolic compounds and anti-acetylcholinase activity of coconut shells." Food Biosci. 2021 Aug;42:101204
9. [IF = 3.932] Yiwen Yang et al."Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters." Ann Transl Med. 2021 Oct; 9(20): 1524
10. [IF = 2.861] Hui-Na Yao et al."Alkaloids with acetylcholinesterase inhibitory activity from Corydalis racemosa (Thunb.) Pers." Natural Product Research. 2019 Dec 07
11. [IF = 1.857] Shi Guiqin et al."Effects of Quercetin on the Growth and Expression of Immune-Pathway-Related Genes in Silkworm (Lepidoptera: bombycidae)." J Insect Sci. 2020 Nov;20(6):
12. [IF = 6.475] Tao-Tao Xue et al."Evaluation of antioxidant, enzyme inhibition, nitric oxide production inhibitory activities and chemical profiles of the active extracts from the medicinal and edition plant: Althaea officinalis." Food Res Int. 2022 Jun;156:111166
13. [IF = 3.493] Hao Zhang et al."A simple and green method for direct determination of hydrogen peroxide and hypochlorite in household disinfectants based on personal glucose meter." Enzyme Microb Tech. 2022 Apr;155:109996
14. [IF = 3.963] Haiyuan Teng et al."Associations between acetylcholinesterase-1 mutations and chlorpyrifos resistance in beet armyworm, spodoptera exigua." PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY. 2022 Apr;:105105

(2-MERCAPTOETHYL)TRIMETHYLAMMONIMUM IODIDE ACETATE - Introduction

Soluble in water, solubility in water: 0.1 g/mL

Last Update：2022-10-16 17:14:35

(2-MERCAPTOETHYL)TRIMETHYLAMMONIMUM IODIDE ACETATE - Reference Information

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
use	substrate for determination of acetylcholinesterase pollution-free vegetable detection technology, biochemical bioassay (also known as enzyme inhibition method, rapid pesticide residue determination method), currently this method mainly extracts acetylcholinesterase from housefly or other animal tissues, acetylcholinesterase is mixed with vegetable sample extract, and iodide acetylthiocholine (ATchI) is used as the substrate, dithiobinitrobenzoic acid (DTNB) is a color developing agent. After a period of time, the degree of acetylcholine inhibition is calculated according to the absorbance value. substrate of acetylcholinesterase, nicotinic acetylcholine receptor agonist. It is often used to determine the activity of acetylcholinesterase by chromaticity method.
category	toxic substances
toxicity classification	poisoning
acute toxicity	vein-mouse LD50:1.800 mg/kg
flammability hazard characteristics	flammability; heating decomposition releases toxic sulfur oxides, nitrogen oxides and iodide fumes
storage and transportation characteristics	warehouse ventilation and low temperature drying
fire extinguishing agent	dry powder, foam, sand, carbon dioxide, mist water