(1S,4S)-2-Benzyl-2,5-diazabicyclo(2.2.1)heptane.2HBr - Names and Identifiers
Name | (1S,4S)-2-Benzyl-2,5-diazabicyclo(2.2.1)heptane.2HBr
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Synonyms | (1R,4R)-2-benzyl-2,5-diazabicyclo[2.2.1]heptane (1S,4S)-2-BENZYL-2,5-DIAZABICYCLO(2.2.1)HEPTANE 2HBR (1S,4S)-2-Benzyl-2,5-diazabicyclo(2.2.1)heptane.2HBr (1S,4S)-2-Phenylmethyl-2,5-diazabicyclo(2.2.1)heptane.2HBr (1S,4S)-2-PHENYLMETHYL-2,5-DIAZABICYCLO(2.2.1)HEPTANE 2HBR (1S,4S)-2-BENZYL-2,5-DIAZABICYCLO[2.2.1]HEPTANE DIHYDROBROMIDE 2-(4-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptane hydrobromide (1S,4S)-2-Benzyl-2,5-diazabicyclo[2.2.1] heptane dihydrobromides (1S,4S)-(+)-2-BENZYL-2,5-DIAZABICYCLO[2.2.1]HEPTANE DIHYDROBROMIDE (1S,4S)-(+)-2-BenzylL-2,5-diazabicyclo-(2,2,1)heptane dihydrobromide (1S,4S)-(+)-2-BenzylL-2,5-diazabicyclo-(2 .2.1)heptane dihydrobromide (1S,4S)-(+)-2-BENZYL-2,5-DI-AZA-BICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE
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CAS | 116258-17-4
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InChI | InChI=1/C11H13ClN2.BrH/c12-8-1-3-10(4-2-8)14-7-9-5-11(14)6-13-9;/h1-4,9,11,13H,5-7H2;1H |
(1S,4S)-2-Benzyl-2,5-diazabicyclo(2.2.1)heptane.2HBr - Physico-chemical Properties
Molecular Formula | C12H18Br2N2
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Molar Mass | 350.09 |
Melting Point | 270°C (dec.)(lit.) |
Boling Point | 387.6°C at 760 mmHg |
Specific Rotation(α) | 16.5 º (C=3 IN 2 M NAOH) |
Flash Point | 188.2°C |
Water Solubility | very faint turbidity |
Vapor Presure | 1.71E-06mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Almost white |
Storage Condition | Room Temprature |
Refractive Index | 16 ° (C=3, 2mol/L Na |
MDL | MFCD01321292 |
(1S,4S)-2-Benzyl-2,5-diazabicyclo(2.2.1)heptane.2HBr - Risk and Safety
Safety Description | 24/25 - Avoid contact with skin and eyes.
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WGK Germany | 3 |
HS Code | 29335990 |
(1S,4S)-2-Benzyl-2,5-diazabicyclo(2.2.1)heptane.2HBr - Introduction
(1S,4S)-2-benzyl -2, 5-diazacyclo [2.2.1] heptane dihydrobromide is a chemical substance with the formula C13H18N2 · 2HBr. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless crystalline solid
-Melting point: about 130-132°C
-Solubility: Soluble in water and polar organic solvents
Use:
(1S,4S)-2-benzyl -2, 5-diazacyclo [2.2.1] heptane dihydrobromide can be used as catalysts and reagents in organic synthesis:
-It can be used as a chiral catalyst to participate in a variety of organic reactions, such as asymmetric hydrogenation reactions, asymmetric nucleophilic addition reactions, etc.
-It can also be used in the synthesis of chiral drugs.
Method:
(1S,4S)-2-benzyl -2, 5-diazacyclo [2.2.1] heptane dihydrobromide is usually prepared by the following steps:
1. Heptane is subjected to a hydrogenation reaction catalyzed by platinum or palladium in the presence of hydrogen to reduce cyclooctane to cyclooctane (cyclohexene).
2. Using amino anion, cyclooctane is converted into (1S,4S)-2-benzyl -2, 5-diazepine [2.2.1] heptane by N-benzylation reaction.
3. Finally, the prepared compound is reacted with hydrochloric acid to generate (1S,4S)-2-benzyl -2, 5-diazacyclo [2.2.1] heptane dihydrobromide.
Safety Information:
- (1S,4S)-2-benzyl -2, 5-diazacyclo [2.2.1] heptane dihydrobromide should be stored in a dry, cool place and away from oxidizing agents.
-Wear personal protective equipment, such as goggles and gloves, to avoid direct contact with the skin and eyes.
-In the process of operation to follow good laboratory practice, pay attention to protective measures and waste disposal.
this is only a brief introduction to (1S,4S)-2-benzyl -2, 5-diazacyclo [2.2.1] heptane dihydrobromide. for more detailed information, please refer to the relevant chemical literature or contact professionals.
Last Update:2024-04-09 21:00:56