(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate
CALCIPOTRIOL MONOHYDRATE
CAS: 147657-22-5
Molecular Formula: C27H40O3.H2O
(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate - Names and Identifiers
(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate - Physico-chemical Properties
| Molecular Formula | C27H40O3.H2O |
| Molar Mass | 430.625 |
| Solubility | Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride. |
| Storage Condition | -20℃ |
| In vitro study | When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner. Treatment of natural killer (NK) cells with drugs modulates their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH) 2 D 3 , Calcipotriol or FTY720 for 4 h. All three concentrations of 1,25(OH) 2 D 3 , Calcipotriol and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation. |
| In vivo study | One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived. Survival is equally distributed between the groups. The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002) compare with placebo (linear regression model). |
(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.322 ml | 11.611 ml | 23.222 ml |
| 5 mM | 0.464 ml | 2.322 ml | 4.644 ml |
| 10 mM | 0.232 ml | 1.161 ml | 2.322 ml |
| 5 mM | 0.046 ml | 0.232 ml | 0.464 ml |
Last Update：2024-01-02 23:10:35
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View History
(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate
32854-45-8
1,2,4-Triazolo[4,3-a]pyrimidine-7-sulfonic acid, 1,5-dihydro-5-thioxo-
2-[(5-benzyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-chlorophenyl)acetamide
N-(2,5-dimethoxyphenyl)-3,4,5-triethoxybenzamide
64584-29-8
6-hydroxy-2,3-dihydro-1-benzofuran-3-one
1261967-65-0
55444-88-7
4-(7-Acetyl-4,6-dihydroxy-3,5-dimethylbenzofuran-2-yl)-2-(1-hydroxyethylidene)-3-oxobutyric acid ethyl ester
32854-45-8
1,2,4-Triazolo[4,3-a]pyrimidine-7-sulfonic acid, 1,5-dihydro-5-thioxo-
2-[(5-benzyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-chlorophenyl)acetamide
N-(2,5-dimethoxyphenyl)-3,4,5-triethoxybenzamide
64584-29-8
6-hydroxy-2,3-dihydro-1-benzofuran-3-one
1261967-65-0
55444-88-7
4-(7-Acetyl-4,6-dihydroxy-3,5-dimethylbenzofuran-2-yl)-2-(1-hydroxyethylidene)-3-oxobutyric acid ethyl ester