Name | (-)-epigallocatechin |
Synonyms | EGC epigallocatechol (-)-epigallocatechol (-)-epigallocatechin antiscurvyfactorc(sub2) 3,3',4',5,5',7-flavanhexol professional supplier Epigallocatechin 970-74-1 2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol (2R,3R)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol 5,7-triol,3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2h-1-benzopyran-(2r-cis |
CAS | 970-74-1 |
EINECS | 619-254-4 |
InChI | InChI=1/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15-/m1/s1 |
InChIKey | XMOCLSLCDHWDHP-IUODEOHRSA-N |
Molecular Formula | C15H14O7 |
Molar Mass | 306.27 |
Density | 1.695±0.06 g/cm3(Predicted) |
Melting Point | 208-210°C |
Boling Point | 685.6±55.0 °C(Predicted) |
Specific Rotation(α) | -50 º (c=0.04, EtOH) |
Flash Point | 368.5°C |
Solubility | Soluble in methanol, ethanol, insoluble in petroleum ether and chloroform. |
Vapor Presure | 9.69E-20mmHg at 25°C |
Appearance | White powder |
Color | White to Light Beige |
Maximum wavelength(λmax) | ['278nm(MeOH)(lit.)'] |
pKa | 9.02±0.15(Predicted) |
Storage Condition | -20°C |
Stability | Stable. Incompatible with strong oxidizing agents. |
Sensitive | Sensitive to heat |
Refractive Index | 1.775 |
MDL | MFCD00075939 |
Physical and Chemical Properties | It is derived from green tea. |
In vitro study | (-)-Epigallocatechin (EGC) is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that (-)-Epigallocatechin prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin and EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot and immunoprecipitation analyses revealed that curcumin and (-)-Epigallocatechin (EGC) specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained [2]. (-)-Epigallocatechin (EGC) exhibits a MIC and MBC of 5 μg/mL and 20 μg/mL respectively and effectively eradicated E. faecalis biofilms. (-)-Epigallocatechin induces the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, (-)-Epigallocatechin induces significant down-regulation of E. faecalis virulence genes [3]. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | KB5100000 |
FLUKA BRAND F CODES | 3-10 |
HS Code | 29329990 |