(叔丁氧羰基)天冬酰胺

(叔丁氧羰基)天冬酰胺 - Names and Identifiers

Name	4-amino-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid
Synonyms	Boc-DL-asparagine TERT-BUTOXYCARBONYL ASPARAGINE N2-(tert-Butoxycarbonyl)asparagine N~2~-(tert-butoxycarbonyl)asparagine Asparagine, N2-[(1,1-dimethylethoxy)carbonyl]- 2-[(tert-butoxycarbonyl)amino]-3-carbamoylpropanoic acid 4-amino-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid 4-AMINO-2-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOBUTANOIC ACID
CAS	142847-17-4
EINECS	231-405-2
InChI	InChI=1/C9H16N2O5/c1-9(2,3)16-8(15)11-5(7(13)14)4-6(10)12/h5H,4H2,1-3H3,(H2,10,12)(H,11,15)(H,13,14)

(叔丁氧羰基)天冬酰胺 - Physico-chemical Properties

Molecular Formula	C9H16N2O5
Molar Mass	232.23
Density	1.253g/cm³
Melting Point	179℃
Boling Point	481.7°C at 760 mmHg
Flash Point	245.1°C
Vapor Presure	1.33E-10mmHg at 25°C
Storage Condition	Room Temprature
Refractive Index	1.496

(叔丁氧羰基)天冬酰胺 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	43 - May cause sensitization by skin contact
Safety Description	36/37 - Wear suitable protective clothing and gloves.

(叔丁氧羰基)天冬酰胺 - Introduction

Boc-DL-Asparagine is an organic compound with the chemical structure Boc-(R)-Asparagine. It is synthesized by reacting aspartic acid with carbamate having Boc protecting group.

Boc-DL-asparagine has the following main properties:
-Appearance: a colorless or almost colorless crystalline powder;
-Molecular formula: C11H18N2O4;
-Molecular weight: 242.27g/mol;
-melting point: about 136-139 ℃;
-Solubility: Good solubility in some organic solvents, such as methanol, chloroform and dichloromethane.

Boc-DL-asparagine is commonly used in organic synthesis protecting group strategy, can protect the amino and carboxyl functional groups of aspartic acid, in order to avoid unnecessary reactions in the synthesis process. After completion of the desired reaction, the Boc group can be removed by deprotection under appropriate conditions, such as acid-catalyzed or fluorinated deprotection, to obtain the original aspartic acid.

Boc-DL-asparagine applications include:
-Protecting group strategy in organic synthesis;
-Synthesis of intermediates in drug development;
-Synthesis of derivatives of natural products.

However, please note the following safety information:
- Boc-DL-Asparagine may cause irritation to the eyes, skin and respiratory tract, so it is necessary to wear appropriate personal protective equipment when handling, such as chemical protective gloves, protective glasses and protective masks;
-Avoid inhalation or exposure to this compound and avoid ingestion;
-Follow good laboratory practices during use and ensure adequate ventilation;
-Seek immediate medical help if accidental exposure or discomfort occurs.

Summary: Boc-DL-Asparagine is a compound used as a protecting group strategy in organic synthesis. It has important application value, but it is necessary to pay attention to safety during operation and follow relevant laboratory operation specifications.

Last Update：2024-04-09 21:32:37