普卡必利, 一种5-HT受体激动剂
Prucalopride
CAS: 179474-81-8
Molecular Formula: C18H26ClN3O3
普卡必利, 一种5-HT受体激动剂 - Names and Identifiers
| Name | Prucalopride |
| Synonyms | CS-219 R093877 Resolor R 093877 Prucalopride 4-Amino-5-chloro-2,3-dihydro-N-(1-(3-methoxypropyl)-4-piperidyl)-7-benzofurancarboxamide 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide |
| CAS | 179474-81-8 |
| EINECS | 1312995-182-4 |
| InChI | InChI=1/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23) |
普卡必利, 一种5-HT受体激动剂 - Physico-chemical Properties
| Molecular Formula | C18H26ClN3O3 |
| Molar Mass | 367.87 |
| Density | 1.28 |
| Melting Point | 90.7° |
| Boling Point | 481.4±45.0 °C(Predicted) |
| Flash Point | 244.9°C |
| Solubility | DMSO 60 mg/mL Water <1 mg/mL Ethanol 38 mg/mL |
| Vapor Presure | 2E-09mmHg at 25°C |
| Appearance | powder |
| Color | white to beige |
| pKa | 13.65±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.599 |
普卡必利, 一种5-HT受体激动剂 - Risk and Safety
| UN IDs | UN 3077 9 / PGIII |
普卡必利, 一种5-HT受体激动剂 - Introduction
Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes.
Last Update：2022-10-16 17:14:31
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View History
普卡必利, 一种5-HT受体激动剂
INOS (MOUSE MACROPHAGE) CDNA PROBE
美罗培南双环母核
TOSLAB 2706
LY2835219(PCB中间体3)6-溴-4-氟-1-异丙基-2-甲基-1H-苯并[D]咪唑
1-甲基-2-吡咯烷酮-d9(Isotopic)
Valeric acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester
乙酮, 1-[2-[(4,6-二氯-2-甲基-5-嘧啶基)氨基]-4,5-二氢-1H-咪唑-1-基]-
5-[[[(2,4-二氟苯基)甲基]氨基]羰基]-1-(2-氧代乙基)-4-氧代-3-苄氧基-1,4-二氢-2-吡啶羧酸甲酯
3-氨基-5-硝基-1-苯并噻吩-2-羧酸甲酯
INOS (MOUSE MACROPHAGE) CDNA PROBE
美罗培南双环母核
TOSLAB 2706
LY2835219(PCB中间体3)6-溴-4-氟-1-异丙基-2-甲基-1H-苯并[D]咪唑
1-甲基-2-吡咯烷酮-d9(Isotopic)
Valeric acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester
乙酮, 1-[2-[(4,6-二氯-2-甲基-5-嘧啶基)氨基]-4,5-二氢-1H-咪唑-1-基]-
5-[[[(2,4-二氟苯基)甲基]氨基]羰基]-1-(2-氧代乙基)-4-氧代-3-苄氧基-1,4-二氢-2-吡啶羧酸甲酯
3-氨基-5-硝基-1-苯并噻吩-2-羧酸甲酯