二苯基环辛炔-四聚乙二醇-活性酯
NHS-PEG4-DBCO
CAS: 1427004-19-0
Molecular Formula: C34H39N3O10
二苯基环辛炔-四聚乙二醇-活性酯 - Names and Identifiers
二苯基环辛炔-四聚乙二醇-活性酯 - Physico-chemical Properties
| Molecular Formula | C34H39N3O10 |
| Molar Mass | 649.69 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| pKa | 15.14±0.46(Predicted) |
| Storage Condition | -20°C |
二苯基环辛炔-四聚乙二醇-活性酯 - Risk and Safety
| WGK Germany | 3 |
二苯基环辛炔-四聚乙二醇-活性酯 - Introduction
NHS-PEG4-DBCO is a chemical reagent, the full name of which is N-hydroxysuccinimide-polyethylene glycol 4-diureidooxyoctanoate (N-hydroxysuccinimide-polyethylene glycol4-dibenzocyclooctyne). Here are some details about this compound:
1. nature: NHS-PEG4-DBCO is a white to light yellow solid. It is a water-soluble compound with good solubility.
2. use: NHS-PEG4-DBCO in biochemistry and biotechnology research has a wide range of applications. It is primarily used as a building block for biomarkers and drug delivery systems. It is capable of highly selective hinge reactions with alkynyl-bearing compounds, such as alkynylated fluorescent dyes or proteins, to form stable covalent linkages. Through this hinge reaction, NHS-PEG4-DBCO can be used for the preparation of targeted drug delivery systems, the construction of fluorescent labeled biological probes and the like.
3. preparation method: the preparation method of NHS-PEG4-DBCO is mainly the reaction of N-hydroxysuccinimide with polyethylene glycol (PEG) and 4-diureido oxo octanoate. This reaction is usually carried out in a non-aqueous solvent such as dimethylimine, chloroform and the like. The synthesis process requires control of reaction conditions and reaction time to ensure high yield and purity.
4. safety information: such as the handling of any chemical reagents, the use of NHS-PEG4-DBCO need to take appropriate safety measures. It should be stored in a dry, well-ventilated place, away from fire and high temperature. Appropriate personal protective equipment, such as lab gloves and safety glasses, should be worn during operation. For further recommendations on the safe handling of this compound, reference should be made to the relevant safety data sheet and the safety operating instructions of the laboratory conducting the relevant study.
1. nature: NHS-PEG4-DBCO is a white to light yellow solid. It is a water-soluble compound with good solubility.
2. use: NHS-PEG4-DBCO in biochemistry and biotechnology research has a wide range of applications. It is primarily used as a building block for biomarkers and drug delivery systems. It is capable of highly selective hinge reactions with alkynyl-bearing compounds, such as alkynylated fluorescent dyes or proteins, to form stable covalent linkages. Through this hinge reaction, NHS-PEG4-DBCO can be used for the preparation of targeted drug delivery systems, the construction of fluorescent labeled biological probes and the like.
3. preparation method: the preparation method of NHS-PEG4-DBCO is mainly the reaction of N-hydroxysuccinimide with polyethylene glycol (PEG) and 4-diureido oxo octanoate. This reaction is usually carried out in a non-aqueous solvent such as dimethylimine, chloroform and the like. The synthesis process requires control of reaction conditions and reaction time to ensure high yield and purity.
4. safety information: such as the handling of any chemical reagents, the use of NHS-PEG4-DBCO need to take appropriate safety measures. It should be stored in a dry, well-ventilated place, away from fire and high temperature. Appropriate personal protective equipment, such as lab gloves and safety glasses, should be worn during operation. For further recommendations on the safe handling of this compound, reference should be made to the relevant safety data sheet and the safety operating instructions of the laboratory conducting the relevant study.
Last Update：2024-04-09 15:18:01
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