Hesperetin
Hesperetin
CAS: 520-33-2;41001-90-5
Molecular Formula: C16H14O6
Hesperetin - Names and Identifiers
| Name | Hesperetin |
| Synonyms | Hesperin Hesperetin HESPERETIN HESPERETINE Hesperetine Hesperitin 4-Methoxy-3,5,7-trihydroxyflavanone 3,5,7-Trihydroxy-4-methoxyflavanone 3',5,7-TRIHYDROXY-4-METHOXYFLAVANONE 3',5,7-Trihydroxy-4'-methoxyflavanone 5,7,3'-TRIHYDROXY-4'-METHOXYFLAVANONE 3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE 4'-Methoxy-3',5,7-trihydroxyflavanone 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one 2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one |
| CAS | 520-33-2 41001-90-5 |
| EINECS | 208-290-2 |
| InChI | InChI=1/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1 |
Hesperetin - Physico-chemical Properties
| Molecular Formula | C16H14O6 |
| Molar Mass | 302.28 |
| Density | 1.458g/cm3 |
| Melting Point | 230-232°C |
| Boling Point | 586.2°C at 760 mmHg |
| Specific Rotation(α) | (C=1.8, EtOH)-4 |
| Flash Point | 223°C |
| Solubility | Easily soluble in ethanol, soluble in dilute alkali solution, partially soluble in ether. Slightly soluble in water, chloroform and benzene. |
| Vapor Presure | 2.45E-14mmHg at 25°C |
| Appearance | Pale yellow needle crystal |
| Storage Condition | 2-8°C |
| Refractive Index | 1.664 |
| MDL | MFCD00075646 |
Hesperetin - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
Hesperetin - Reference
| Reference Show more | 1. Liu Yuhua, Wang Dan, Yang Dan, et al. Optimization of ultrasonic-assisted extraction of desert GA seeds by response surface methodology [J]. Journal of Liaoning University of Traditional Chinese Medicine 2018 v.20;No.169(05):59-61. 2. Wang Lifang, Liu Dayin, Zhao Fangyan, etc. Apoptosis-inducing effect of hesperetin on SW480 colon cancer cells [J]. Chinese Journal of Clinical Pharmacology,, 035(021):2695-2697,2705. 3. Xue Bao, sangweilin, Jiang Yafei, etc. Experimental study on the regulation of chondrocyte inflammatory degeneration by inhibiting NF-κB pathway of hesperetin [J]. Advances in modern biomedicine, 2019, 19(04):18-23. 4. Mao Chen Mei, Yu Dan red, Gui ring. Mechanism of hesperetin inhibiting P-selectin-induced breast cancer metastasis [J]. Chinese herbal medicine, 2017(4). 5. Zhang Zhi-min, NEI-min, Li Ya-Mei, et al. Evaluation of consistency and difference of fructus aurantii from different habitats by cluster analysis and principal component analysis [J]. Asia-Pacific traditional medicine, 2019, 015(004):30-36. 6. Huang Huahua, Zhang Weiyun, Chen Jinghai, etc. Study on improving the quality standard of tangerine peel dispensing granules [J]. China Pharmacy, 2019, 030(007):937-941. 7. Zhou Jia, Cai Hao, Duan Yu, etc. Quantitative analysis of 16 main chemical components in aqueous extract of Sini powder based on UHPLC-QqQ-MS [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2019, v.35(01):91-95. 8. Han Xing, Li Xueyan, Yang Haiyang, et al. Screening of quality control components of Chrysanthemum Water extract and its network pharmacological effects [J]. China Pharmacy, 2019, 030(023):3258-3265. 9. Gao Xi-Mei, Chi Yu-Mei, Zhang Wen, etc. Study on quality evaluation of Citrus aurantium by fingerprint combined with one-Test multi-evaluation method [J]. Chinese herbal medicine, 2020, v.51;No.668(09):281-289. 10. Xie Hui, Chen, ya Lei, Ai Ling, et al. Simultaneous determination of flavanones and nobiletin in citrus medicinal resources by SPE-HPLC-DAD method [J]. Natural product research and development 2019(8). 11. Jiang Jialu, Sun Hui, Ni Jie, Xu Dangcheng, Song Mengmeng, Yao Weifeng, Cheng Haibo, Kang An, Sun Dongdong. Effects of intestinal flora on metabolism of active components and inhibition of CYP1A1 in Scutellaria Barbata [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2021,37(02):225-230. 12. Xu Yanyang, Zhao Yujuan, Gao Feng, Wang erlei, Lu hailing, Li Xuefeng, Jiang Wenwen, Chen Yan. Analysis of polyphenols in different parts of Chinese ginseng by high performance liquid chromatography [J]. Food Science, 2021,42(04):240-246. 13. Li Wenfeng, Zhang Xiangyang, Wang Cui, Lin Lanting, Chen Xiaoping, Qu Yang, Zhang Xuemei, Lin Yao, Tan Yan, Zheng Nigran, Gao Xiaoxu. Drying kinetics and Polyphenol degradation kinetics of tumorous stem mustard by gas jet impingement [J]. Food Science, 2021,42(05):106-114. 14. Wang, Peng, et al. "Chemical and genetic discrimination of commercial Guangchenpi (Citrus reticulata 'Chachi') by using UPLC-QTOF-MS/MS based metabolomics and DNA barcoding approaches." RSC advances 9.40 (2019): 23373-23381.https://doi.org/10.1039/C9RA0374 15. He, Wei, et al. "Citrus aurantium L. and its flavonoids regulate TNBS-induced inflammatory bowel disease through anti-inflammation and suppressing isolated jejunum contraction ." International journal of molecular sciences 19.10 (2018): 3057.https://doi.org 16. Wang, Si-wei, et al. "Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway." International Immunopharmacology 89 (2020): 107036.https://doi.org/10.1016/j.intimp.2020.107036 17. Qian, Xiyi, and Fei Zhu. "Hesperetin protects crayfish Procambarus clarkii against white spot syndrome virus infection ." Fish & shellfish immunology 93 (2019): 116-123.https://doi.org/10.1016/j.fsi.2019.07.029 18. Guo, Xiao, et al. "Intestinal absorption and distribution of naringin, hesperidin, and their metabolites in mice." Journal of Functional Foods 74 (2020): 104158.https://doi.org/10.1016/j.jff.2020.104158 19. He, Wei, et al." Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity." European journal of pharmacology 857 (2019): 172456.https://doi.org/10.1016/j.ejphar.2019.172456 20. [IF=7.514] Jing Zhao et al."A sensitive and practical ELISA for analyzing naringenin in pummelo and herb samples."Food Chem. 2021 Nov;362:130223 21. [IF=6.543] Wang Yue et al."Polymethoxyflavones in Citrus Regulate Lipopolysaccharide-Induced Oscillating Decay of Circadian Rhythm Genes by Inhibiting Nlrp3 Expression."Oxid Med Cell Longev. 2021;2021:8419415 22. [IF=5.279] Feng Wang et al."Four Citrus Flavanones Exert Atherosclerosis Alleviation Effects in ApoE-/- Mice via Different Metabolic and Signaling Pathways."J Agr Food Chem. 2021;69(17):5226-5237 23. [IF=4.952] Si Tan et al."The effects of drying methods on chemical profiles and antioxidant activities of two cultivars of Psidium guajava fruits."Lwt Food Sci Technol. 2020 Jan;118:108723 24. [IF=4.581] Xiyi Qian et al."Hesperetin protects crayfish Procambarus clarkii against white spot syndrome virus infection."Fish Shellfish Immun. 2019 Oct;93:116 25. [IF=4.451] Xiao Guo et al."Intestinal absorption and distribution of naringin hesperidin, and their metabolites in mice."J Funct Foods. 2020 Nov;74:104158 26. [IF=4.432] Wei He et al."Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity."Eur J Pharmacol. 2019 Aug;857:172456 27. [IF=4.411] Liuyi Yu et al."Systematic Detection and Identification of Bioactive Ingredients from Citrus aurantium L. var. amara Using HPLC-Q-TOF-MS Combined with a Screening Method."Molecules. 2020 Jan;25(2):357 28. [IF=4.268] Si-wei Wang et al."Hesperetin promotes DOT1L degradation and reduces histone H3K79 methylation to inhibit gastric cancer metastasis."Phytomedicine. 2021 Apr;84:153499 29. [IF=3.943] Si-wei Wang et al."Hesperetin, a SIRT1 activator inhibits hepatic inflammation via AMPK/CREB pathway."Int Immunopharmacol. 2020 Dec;89:107036 30. [IF=3.935] Jingyun Zheng et al."A systematic investigation on free phenolic acids and flavonoids profiles of commonly consumed edible flowers in China."J Pharmaceut Biomed. 2019 Aug;172:268 31. [IF=3.638] Wenfeng Li et al."Zein enhanced the digestive stability of five citrus flavonoids via different binding interaction."Journal Of The Science Of Food And Agriculture. 2022 Mar 09 32. [IF=3.307] Juan Liu et al."Production of hesperetin from naringenin in an engineered Escherichia coli consortium."J Biotechnol. 2022 Mar;347:67 |
Hesperetin - Introduction
Hesperetin(Hesperetin) is a naturally occurring flavonoid that is commonly found in citrus fruits. The following is a description of the nature, use, preparation and safety information of the Hesperetin:
Nature:
-Appearance: Yellow crystalline or crystalline powder
-Solubility: Soluble in hot ethanol and sodium hydroxide solution, slightly soluble in water and ether
-Melting point: about 230-233°C
Use:
-Pharmaceutical applications: Hesperetin has antioxidant, anti-inflammatory, anti-tumor, anti-allergic, anti-platelet aggregation and other activities, and has the role of promoting vasodilation and regulating blood lipids. Therefore, it is widely used in the preparation of health products and drugs, such as anti-allergy drugs, cardiovascular disease drugs, etc.
-Cosmetic applications: Hesperetin can also be used in cosmetics as antioxidants, whitening agents and anti-aging agents.
Preparation Method:
- Hesperetin is usually obtained by extraction from citrus fruits, and then purified and synthesized through chemical reactions. The most common extraction method is the use of acidic solutions (e. g. acetic acid). Subsequently, it can be purified by crystallization, chromatography, etc.
Safety Information:
- Hesperetin is considered safe under general conditions of use, it is still necessary to follow the correct method of use and dosage.
-For certain groups of people, such as pregnant women, lactating women, and certain drug-sensitive people, consult a doctor before use.
-Follow the correct operating procedures and safety measures when using, and avoid contact with eyes and skin.
Nature:
-Appearance: Yellow crystalline or crystalline powder
-Solubility: Soluble in hot ethanol and sodium hydroxide solution, slightly soluble in water and ether
-Melting point: about 230-233°C
Use:
-Pharmaceutical applications: Hesperetin has antioxidant, anti-inflammatory, anti-tumor, anti-allergic, anti-platelet aggregation and other activities, and has the role of promoting vasodilation and regulating blood lipids. Therefore, it is widely used in the preparation of health products and drugs, such as anti-allergy drugs, cardiovascular disease drugs, etc.
-Cosmetic applications: Hesperetin can also be used in cosmetics as antioxidants, whitening agents and anti-aging agents.
Preparation Method:
- Hesperetin is usually obtained by extraction from citrus fruits, and then purified and synthesized through chemical reactions. The most common extraction method is the use of acidic solutions (e. g. acetic acid). Subsequently, it can be purified by crystallization, chromatography, etc.
Safety Information:
- Hesperetin is considered safe under general conditions of use, it is still necessary to follow the correct method of use and dosage.
-For certain groups of people, such as pregnant women, lactating women, and certain drug-sensitive people, consult a doctor before use.
-Follow the correct operating procedures and safety measures when using, and avoid contact with eyes and skin.
Last Update：2024-04-09 02:00:46
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View History
Hesperetin
37576-04-8
1H-Azepine, 1-(4,5-dihydro-2-oxazolyl)hexahydro-
3454-04-4
90614-07-6
146539-83-5
formicacid,lead(2++)salt
59493-82-2
2,3-Bis(4-hydroxyphenyl)propanenitrile
N-(1-adamantylmethyl)-2-(4-butoxyphenyl)-4-quinolinecarboxamide
37576-04-8
1H-Azepine, 1-(4,5-dihydro-2-oxazolyl)hexahydro-
3454-04-4
90614-07-6
146539-83-5
formicacid,lead(2++)salt
59493-82-2
2,3-Bis(4-hydroxyphenyl)propanenitrile
N-(1-adamantylmethyl)-2-(4-butoxyphenyl)-4-quinolinecarboxamide