中文名 | 美托拉宗 |
英文名 | Metolazone |
别名 | 甲醋唑胺 美托拉宗 美托拉腙 米托拉腙 甲苯喹唑酮 美托拉宗杂质 美托拉宗(标准品) 美托拉索 EP标准品 7-氯-1,2,3,4-四氢-2-甲基-3-(2-甲基苯基)-4-氧代-6-喹唑磺酰胺 |
英文别名 | Xuret Diulo Mykrox s720-22 Normelan Zaroxolyn Metolazone amino 7-chloro-2-methyl-3-(o-tolyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonate 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI) 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro- 2-methyl-3-(2-methylphenyl)-4-oxo- 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- (9CI) 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, SR-720-22, Diulo, Metenix, Mykrox, Oldren, |
CAS | 17560-51-9 |
EINECS | 241-539-3 |
化学式 | C16H16ClN3O3S |
分子量 | 365.83 |
InChI | InChI=1/C16H16ClN3O4S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(25(22,23)24-18)7-11(13)16(20)21/h3-8,10,19H,18H2,1-2H3 |
InChIKey | AQCHWTWZEMGIFD-UHFFFAOYSA-N |
密度 | 1.2895 (rough estimate) |
熔点 | 252-254°C |
沸点 | 613.6±65.0 °C(Predicted) |
闪点 | 322.9°C |
水溶性 | 60.3mg/L(25 ºC) |
蒸汽压 | 7.82E-15mmHg at 25°C |
溶解度 | DMSO: >5 mg/mL |
折射率 | 1.6100 (estimate) |
酸度系数 | pKa 9.7 (Uncertain) |
存储条件 | 2-8°C |
稳定性 | 2年稳定供应。DMSO中的溶液可以在-20 °C干燥储存长达2个月。 |
外观 | 固体 |
颜色 | white |
体外研究 | Metolazone (SR-720-22) is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and is excreted as urine, instead of being reabsorbed into the bloodstream. Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels. Nevertheless, they can be associated with low sodium levels, volume depletion, and low blood pressure, among other adverse effects. |
WGK Germany | 2 |
RTECS | VA1700000 |
海关编号 | 2935904000 |
上游原料 | 三氯化磷 |