中文名 | 磺胺吡啶 |
英文名 | Sulfapyridine |
别名 | 磺胺吡啶 2-磺胺吡啶 磺胺吡啶熔点标准物 柳氮磺胺吡啶EP杂质J 柳氮磺吡啶杂质J (EP) 对胺-N-2-吡啶苯磺醯胺 對胺-N-2-吡啶苯磺醯胺 柳氮磺胺吡啶杂质J (EP) 4-氨基-N-(2-吡啶基)苯磺酰胺 |
英文别名 | THAP11 CTG-B43a CTG-B45d HRIHFB2206 Sulfapyridine Sulfapyridine (Dagenan) Sulfapyridine Solution, 100ppm Monoclonal Anti-THAP11 antibody produced in mouse 2-(4-Aminobenzenesulfonamido)pyridineN'-2-Pyridylsulfanilide2-Sulfanilamidopyridine |
CAS | 144-83-2 |
EINECS | 205-642-7 |
化学式 | C11H11N3O2S |
分子量 | 249.29 |
InChI | InChI=1/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14) |
密度 | 1.3220 (rough estimate) |
熔点 | 191-193°C |
沸点 | 473.5±51.0 °C(Predicted) |
闪点 | 240.2°C |
蒸汽压 | 3.9E-09mmHg at 25°C |
溶解度 | DMSO (微溶) 、甲醇 (微溶) |
折射率 | 1.6740 (estimate) |
酸度系数 | pKa 8.48(H2Ot = 25I = 0.05) (Uncertain) |
存储条件 | Keep in dark place,Sealed in dry,Room Temperature |
稳定性 | 稳定。可燃。保护光线。与强氧化剂不相容。 |
外观 | 整洁 |
颜色 | White to Off-White |
Merck | 14,8938 |
BRN | 222065 |
物化性质 | 黄棕至白色粉末。熔点191-193℃。微溶于水。 |
MDL号 | MFCD00038036 |
体外研究 | Sulfapyridine inhibits production of IL-8, chemokine (C-X-C motif) ligand 1 (CXCL1), and monocyte chemotactic protein-1 (MCP-1) in synovial cells of rheumatoid arthritis (RA). MIC range of Sulfapyridine for Y. enterocolitica is 3.1-25 μg/mL and for Salmonella 25-100 μg/mL. Campylobacter jejuni/coli are less susceptible to Sulfapyridine with MIC values ranging from 200 to 800 μg/mL. Shigella and three of five E. coli strains are resistant to 1600 μg/mL of sulfapyridine. Two strains of E. coli are inhibited by 25 μg/mL. |
体内研究 | Sulfapyridine (1 and 10 μg/kg; i.p.) significantly inhibits systemic allergic reaction induced by compound 48/80 in rats. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 2 |
RTECS | DA9625000 |
海关编号 | 29350010 |
Hazard Class | IRRITANT |
上游原料 | 4-氯-N-(吡啶-2-基)苯磺酰胺 对乙酰胺基苯磺酰氯 结晶磺胺 |
下游产品 | 柳氮磺吡啶 |
参考资料 展开查看 | 1. [IF=7.46] Zijun Xu et al."Machine learning assisted dual-emission fluorescence/colorimetric sensor array detection of multiple antibiotics under stepwise prediction strategy."Sensor Actuat B-Chem. 2022 May;359:131590 |