中文名 | 环芬尼 |
英文名 | cyclofenil |
别名 | 环芬尼 双氯胍 双醋环烷 环己基亚甲基二苯酚二乙酸酯 |
英文别名 | CFN f6066 F 6066 H 3452 Oginex Sexovar Sexovid Neoclym Ondonid Rehibin Ondogyne Fertodur Sexadieno AI3-52271 NSC 86464 ICI 48213 cyclofenyl Cyclopenil Cyclofenyl cyclofenil Cyclophenyl Cyclophenil cyclophenyl Ciclofenilo BRN 2014687 cyclophenil Cyclofenilum UNII-J468V64WZ1 Cyclofenilum [INN-Latin] Ciclofenilo [INN-Spanish] bis-(p-acetoxyphenyl)-cyclohexylidenemethane 4,4'-(Cyclohexylidenmethylen)diphenyl diacetat Bis(p-hydroxyphenyl)cyclohexyldienemethane diacetate bis-(p-hydroxyphenyl)-cyclohexylidenemethanediacetate Bis-(p-hydroxyphenyl)-cyclohexylidenemethane diacetate 4,4'-(Cyclohexylidenemethylene)diphenol diacetate ester (cyclohexylidenemethanediyl)dibenzene-4,1-diyl diacetate 4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)-phenoacetate alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)-p-cresodiacetate p-Cresol, alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)-, diacetate Phenol, 4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)-, acetate (9CI) |
CAS | 2624-43-3 |
EINECS | 220-089-1 |
化学式 | C23H24O4 |
分子量 | 364.44 |
InChI | InChI=1/C23H24O4/c1-16(24)26-21-12-8-19(9-13-21)23(18-6-4-3-5-7-18)20-10-14-22(15-11-20)27-17(2)25/h8-15H,3-7H2,1-2H3 |
密度 | 1.0986 (rough estimate) |
熔点 | 135-136° |
沸点 | 415.62°C (rough estimate) |
闪点 | 254.8°C |
蒸汽压 | 1.77E-10mmHg at 25°C |
溶解度 | DMSO: 60 °C时10mg/mL,可溶 |
折射率 | 1.4433 (estimate) |
存储条件 | 2-8°C |
外观 | 固体 |
颜色 | White to Off-White |
体外研究 | Cyclofenil shows an inhibitory effect on dengue virus (DENV) replication in mammalian cells but not in mosquito cells. Cyclofenil also inhibits the replication of Zika virus. A time-of-addition assay suggested that Cyclofenil may interfere with two stages of the Dengue virus (DENV) life cycle: the translation-RNA synthesis and assembly-maturation stages. The level of intracellular infectious particles decreased more drastically after treatment with Cyclofenil than the viral RNA level do, indicating that the assembly-maturation stage might be the main target of Cyclofenil. |
体内研究 | The number of estrogen receptors α (ERα) and β (ERβ)-immunoreactive (-ir) cells is determined of each stage of the estrous cycle in intact rats. Additionally, the effects of blocking ERα and ERβ on ovulation rate on diestrus-2 or proestrus day through the microinjection of methyl-piperidino-pyrazole (MPP) or Cyclofenil in either side of preoptic-anterior hypothalamic area (POA-AHA) are evaluated. The number of ERα-ir and ERβ-ir cells in POA-AHA varied in each phase of estrous cycle. Either MPP or Cyclofenil in the right side of POA-AHA on diestrus-2 day reduced the ovulation rate, while at proestrus day it was decreased in rats treated in either side with MPP, and in those treated with Cyclofenil in the left side. MPP or Cyclofenil produced a decrease in the surge of luteinizing hormone levels (LH) and an increase in progesterone and follicle stimulating hormone (FSH). |
WGK Germany | 2 |
RTECS | GO7550000 |
上游原料 | 4-溴苯甲醚 |