中文名 | 丁硫氨酸-亚砜亚胺 |
英文名 | 2-amino-4-(S-butylsulfonimidoyl)butanoic acid |
别名 | 丁基硫 丁硫氨酸-亚砜亚胺 DL-丁硫氨酸亚砜 丁硫胺酸亚砜胺(BSO) DL-丁硫氨酸-S,R-磺基 DL-丁硫氨酸-(S,R)-亚砜胺 DL-丁硫氨酸(S,R)-亚砜亚胺 DL-丁硫氨酸-(S,R)-亚砜亚胺 DL-(3-氨基-4-羧丙基)-(S,R)-丁基硫氧亚胺 |
英文别名 | buthioninesulfoxamine buthioninesulfoximine DL-BUTHIONINE-SULFOXIMINE DL-BUTHIONINE (S,R)-SULPHOXIME DL-BUTHIONINE-[S,R]-SULFOXIMINE DL-BUTHIONINE (R,S)-SULFOXIMINE 2-amino-4-(s-butylsulfonimidoyl)butanoicacid 2-amino-4-(s-butylsulfonimidoyl)-butanoicaci 2-amino-4-(S-butylsulfonimidoyl)butanoic acid |
CAS | 5072-26-4 71765-30-5 83730-53-4 |
EINECS | 628-045-7 |
化学式 | C8H18N2O3S |
分子量 | 222.31 |
InChI | InChI=1/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12) |
密度 | 1.29±0.1 g/cm3(Predicted) |
熔点 | 215°C (dec.)(lit.) |
沸点 | 382.3±52.0 °C(Predicted) |
闪点 | 185°C |
蒸汽压 | 6.64E-07mmHg at 25°C |
溶解度 | H2O: 50mg/ml,澄清,无色 |
折射率 | 1.537 |
存储条件 | 2-8°C |
外观 | 蓬松粉 |
颜色 | White |
Merck | 13,1520 |
BRN | 2367136 |
MDL号 | MFCD00067000 |
体外研究 | Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine. |
体内研究 | Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
WGK Germany | 3 |
RTECS | EK7713435 |
FLUKA BRAND F CODES | 10 |
海关编号 | 29309090 |
下游产品 | 水星 |
参考资料 展开查看 | 1. Li, Bingqiang, et al. "A dual pH-and reduction-responsive anticancer drug delivery system based on PEG–SS–poly (amino acid) block copolymer." RSC advances 7.48 (2017): 30242-30249. 2. [IF=3.361] Bingqiang Li et al."A dual pH- and reduction-responsive anticancer drug delivery system based on PEG–SS–poly(amino acid) block copolymer."Rsc Adv. 2017 Jun;7(48):30242-30249 3. [IF=3.239] Gang Luo et al."The mechanism of N-acetyl-l-cysteine in improving the secretion of porcine follicle-stimulating hormone in Pichia pastoris."Yeast. 2021 Nov;38(11):601-611 |